General Receptor for phosphoinositides 1; GRASP1; General receptor for phosphoinositides 1-associated scaffold protein; GRASP; GRASP_HUMAN; GRP1 (general receptor for phosphoinositides 1) associated scaffold protein; GRP1 associated scaffold protein; GRP1-associated scaffold protein; Tamalin.
规格价格
100ul/2980元 购买 大包装/询价
说 明 书
100ul
研究领域
神经生物学 细胞膜受体 细胞骨架
抗体来源
Rabbit
克隆类型
Polyclonal
交叉反应
Human, Mouse, Rat, Dog, Pig, Cow, Horse,
产品应用
ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量
45kDa
细胞定位
细胞膜
性 状
Lyophilized or Liquid
浓 度
1mg/ml
免 疫 原
KLH conjugated synthetic peptide derived from human GRASP/General Receptor for phosphoinositides 1
亚 型
IgG
纯化方法
affinity purified by Protein A
储 存 液
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍
background: This gene encodes a protein that functions as a molecular scaffold, linking receptors, including group 1 metabotropic glutamate receptors, to neuronal proteins. The encoded protein contains conserved domains, including a leucine zipper sequence, PDZ domain and a C-terminal PDZ-binding motif. Alternately spliced transcript variants have been observed for this gene.[provided by RefSeq, Dec 2012]
Function: Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses.
Subunit: Heteromer. Composed of GRASP, PSCD2 and at least one GRM1. Also interacts with PSCD3, GRM2, GRM3 and GRM5
Subcellular Location: Cytoplasm, perinuclear region (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity). Note=Localized at postsynaptic membranes.
Similarity: Contains 1 PDZ (DHR) domain.
Database links:
Entrez Gene: 160622 Human
Entrez Gene: 56149 Mouse
Entrez Gene: 192254 Rat
Omim: 612027 Human
SwissProt: Q7Z6J2 Human
SwissProt: Q9JJA9 Mouse
SwissProt: Q8R4T5 Rat
Unigene: 407202 Human
Unigene: 621295 Human
Unigene: 276573 Mouse
Unigene: 82758 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.