一种PLK1(Polo-like Kinase 1)抑制剂。SBE 13 hydrochloride is a selective inhibitor of PLK1 (IC50 values are 200 pM, 875 nM and 66 μM for PLK1, PLK3 and PLK2 respectively). SBE 13 hydrochloride targets the inactive conformation of PLK1, and exhibits no effect on Aurora kinase A activity. Binds and stabilizes the inactive form of PLK1. This compound delays cell cycle progression, reduces cell proliferation and induces apoptosis in a range of human cancer cell lines.