靶点/蛋白:ABD11031 recognises human Autophagy-related protein 7, known also as Ubitiquin Activating Enzyme-E1 like Protein, ATG7 and APG7, a 78kDa cytoplasmic protein. In mammalian cells, ATG7 is essential for autophagy conjugation systems, autophagosome formation, starvation-induced bulk degradation of proteins and organelles. Studies indicate that caspase-8 may alter APG7 levels and thus the APG7 program of autophagic cell death. ATG7 is evolutionally conserved and exhibits high homology within mammalian species. It expressed in wide range of tissues including kidney, live, bone marrow and lymph nodes.