首页 / 试剂 /  / 其它酶 / AMPK(A2/B1/G1),active enzymes

我的询价

99
商家已回复你的询价 【点击查看】

询价列表

暂时没有已询价产品

当你希望让更多商家联系你时,可以勾选后发送询价,平台会将你的询价消息推荐给更多商家。
个人收货地址

编辑个人收货信息

AMPK(A2/B1/G1),active enzymes

收藏

AMPK(A2/B1/G1),active enzymes

丁香通采购保障计划,让您的采购更放心。 查看详情

  • 商家诚信度 
  • 入驻年限  3年
  • 广州市天河区天河北路194号合晖街401

站内推广

  • 货号: P48-10H-10
    CAS号: 咨询商家
    供应商: 星燎
    数量: 99
    英文名: AMPK(A2/B1/G1),active enzymes
    保质期: 咨询商家
    保存条件: –70
    规格: 10ug
    Description: Recombinant full-length human AMPK (combination of A2/B1/G1 subunits) was expressed by baculovirus in Sf9 insect cells using a C-terminal His tags.

     
         Species: Human

     
         Tag: HIS tags

     
         Expression System: Sf9 insect cells using baculovirus

     
         Sequence: Full Length

     
         Genbank Number: NM_006252  NM_006253  NM_002733

     
         
    Specific Activity : Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet. 



    Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 



    Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. 

    Applications : Kinase Assay, Western Blot 

    Molecular Weight : ~69kDa (A2), ~38kDa (B1), and ~40kDa (G1). 

    Gene Aliases : Subunits A2: PRKAA2, AMPK, AMPK2, PRKAA Subunit B1: PRKAB1, AMPK, HAMPKb, MGC17785 Subunit G1: PRKAG1, AMPKG, MGC8666 

    Scientific Background : AMPK (A2/B1/G1) plays a key role in insulin signaling pathway and is a major therapeutic target for the treatment of diabetes (1). AMPK is viewed as a fuel sensor for glucose and lipid metabolism by modulating the activity of the autonomous nervous system in vivo. Short-term overexpression of a constitutively active form of AMPK in the liver leads to mild hypoglycemia and fatty liver due to increased fatty acid utilization (2). 

    References : 
    1. Viollet, B. et al: Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models. Biochem. Soc. Trans. 2003; 31; 216–219. 

    2. Foretz, M. et al: Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. Diabetes, 2005; 54 (5);1331-1339. 

    Formulation : 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. 
    温馨提示:不可用于临床治疗。

询价发送成功

会在1个工作日内联系您!

马上登录注册,即可保存询价历史

你可能感兴趣的产品