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    AMPK(A2/B1/G1),active enzymes

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    AMPK(A2/B1/G1),active enzymes

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    • 货号: P48-10H-10
      CAS号: 咨询商家
      供应商: 星燎
      数量: 99
      英文名: AMPK(A2/B1/G1),active enzymes
      保质期: 咨询商家
      保存条件: –70
      规格: 10ug
      Description: Recombinant full-length human AMPK (combination of A2/B1/G1 subunits) was expressed by baculovirus in Sf9 insect cells using a C-terminal His tags.

       
           Species: Human

       
           Tag: HIS tags

       
           Expression System: Sf9 insect cells using baculovirus

       
           Sequence: Full Length

       
           Genbank Number: NM_006252  NM_006253  NM_002733

       
           
      Specific Activity : Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet. 



      Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 



      Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. 

      Applications : Kinase Assay, Western Blot 

      Molecular Weight : ~69kDa (A2), ~38kDa (B1), and ~40kDa (G1). 

      Gene Aliases : Subunits A2: PRKAA2, AMPK, AMPK2, PRKAA Subunit B1: PRKAB1, AMPK, HAMPKb, MGC17785 Subunit G1: PRKAG1, AMPKG, MGC8666 

      Scientific Background : AMPK (A2/B1/G1) plays a key role in insulin signaling pathway and is a major therapeutic target for the treatment of diabetes (1). AMPK is viewed as a fuel sensor for glucose and lipid metabolism by modulating the activity of the autonomous nervous system in vivo. Short-term overexpression of a constitutively active form of AMPK in the liver leads to mild hypoglycemia and fatty liver due to increased fatty acid utilization (2). 

      References : 
      1. Viollet, B. et al: Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models. Biochem. Soc. Trans. 2003; 31; 216–219. 

      2. Foretz, M. et al: Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. Diabetes, 2005; 54 (5);1331-1339. 

      Formulation : 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. 
      温馨提示:不可用于临床治疗。

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