Recombinant Mouse CD157/BST1 (CU13)
产品说明(Description)
Recombinant Mouse ADP-ribosyl Cyclase/cyclic ADP-ribose Hydrolase 2 is produced by our Mammalian expression system and the target gene encoding Ala25-Glu285 is expressed with a 6His tag at the C-terminus.
Accession #: Q64277
Known as: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; ADP-ribosyl cyclase 2; Antigen BP3; BP-3 alloantigen; Bone marrow stromal antigen 1; BST-1; Cyclic ADP-ribose hydrolase 2; cADPr hydrolase 2; Leukocyte antigen 65; Ly-65; CD157; Bst1; Bp-3; Bp3; Ly65
制剂(Formulation)
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
质量控制(Quality Control)
Purity: Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin: Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
复溶(Reconstitution)
Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
保存(Storage)
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
背景(Background)
CD157 is a glycosyl phosphatidylinositol anchored membrane protein that belongs to the CD38 family. CD157 was discovered in a bone marrow stromal cell line where it facilitates preBcell growth. Along with CD38, CD157 is a bifunctional ectoenzyme that exhibits both ADP-ribosyl cyclase and cyclic ADP ribose hydrolase activities. It may play a role in rheumatoid arthritis (RA) due to its enhanced expression in RA-derived bone marrow stromal cell lines. CD157 has been predicted to function as a cell surface receptor and an immunoregulatory molecule. CD157 was originally identified as a bone marrow stromal cell molecule (BST-1) with a glycosylphosphatidylinositol (GPI) anchor to bind to the cell surface. CD157 is prevalently expressed by cells of the myeloid lineage. CD157 could act as a receptor with signal transduction capability. Further, it regulates calcium homeostasis and promotes polarization in neutrophils and mediates superoxide (O2?) production in the human U937 myeloid line.
电泳(SDS-PAGE)
FOR RESEARCH USE ONLY