XE-991 dihydrochloride

概述

• 产品名称
  XE-991 dihydrochloride
• 描述
  Potent， selective KCNQ channel blocker; blocks M current
• 生物学描述
  Potent and selective blocker of KCNQ voltage-gated potassium channels. Blocks M current. (IC₅₀ values are 0.98 μM (M-current), 0.71 μM (KCNQ 2), 0.75 μM (KCNQX 1), >100 μM (Kv1.2) and >43 μM (Kv4.3). Potent pulmonary vasoconstrictor. Cognitive enhancer following oral administration in vivo.
• 纯度
  > 99%

性能

• 化学名称

  10,10-Bis(4-pyridinylmethyl)-9(10H)-anthracenone dihydrochloride

• 分子量
  449.40
• 化学结构
  
• 分子式
  C₂₆H₂₀N₂O.2HCl
• CAS编号
  122955-13-9
• 存放说明
  Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
• 溶解度概述

  Soluble in water to 100 mM

• 处理

  Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

• 来源

  Synthetic