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骨成型蛋白受体1A抗体

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骨成型蛋白受体1A抗体
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  • 入驻年限  3年
  • 上海闵行区元江路5500号第1幢5658室
  • 货号: YS-1509R
    抗体英文名: BMPR1A
    浓度: 2287mg/ml
    应用范围: ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-2790 (石蜡切片需做抗原修复) not yet tested in other applications.
    宿主: Rabbit
    标记物: FITC
    克隆性: 多克隆
    保存条件: -20℃保存
    形态: 液态/冻干粉
    亚型: IgG
    规格: 100微笑
    英文名称BMPR1A
    中文名称骨成型蛋白受体1A抗体
    别    名BMPR-1A; Activin A receptor type II like kinase 3; Activin receptor like kinase 3; ACVRLK 3; ACVRLK3; ALK 3; ALK3; BMPR 1A; Bmpr; Bone morphogenetic protein receptor type IA; Bone morphogenetic protein receptor type IA precursor; BR 1a; BR1a; CD 292; CD292; CD292 antigen; EC 2.7.11.30; Serine threonine protein kinase receptor R5; Serine threonine protein kinase receptor R5 precursor; SKR 5; SKR5; zBMPR IA; zBMPRIA.  
    说 明 书50ul  100ul  200ul
    研究领域肿瘤  心血管  细胞生物  信号转导  干细胞  生长因子和激素  转录调节因子  激酶和磷酸酶  细胞膜受体  细胞表面分子  
    抗体来源Rabbit
    克隆类型Polyclonal
    交叉反应 Human, Mouse, Rat, 
    骨成型蛋白受体1A抗体产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复) 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量60kDa
    细胞定位细胞膜 
    性    状Lyophilized or Liquid
    浓    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human BMPR-1A:101-200/532 <Extracellular>
    亚    型IgG
    纯化方法affinity purified by Protein A
    储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    PubMedPubMed
    产品介绍background:
    The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq].
     
    Function:
    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4.
     
    Subcellular Location:
    Membrane; Single-pass type I membrane protein.
     
    Tissue Specificity:
    Highly expressed in skeletal muscle.
     
    DISEASE:
    Defects in BMPR1A are a cause of juvenile polyposis syndrome (JPS) [MIM:174900]; also known as juvenile intestinal polyposis (JIP). JPS is an autosomal dominant gastrointestinal hamartomatous polyposis syndrome in which patients are at risk for developing gastrointestinal cancers. The lesions are typified by a smooth histological appearance, predominant stroma, cystic spaces and lack of a smooth muscle core. Multiple juvenile polyps usually occur in a number of Mendelian disorders. Sometimes, these polyps occur without associated features as in JPS; here, polyps tend to occur in the large bowel and are associated with an increased risk of colon and other gastrointestinal cancers.
    Defects in BMPR1A are a cause of Cowden disease (CD) [MIM:158350]. CD is an autosomal dominant cancer syndrome characterized by multiple hamartomas and by a high risk for breast, thyroid and endometrial cancers.
     
    Similarity:
    Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. 
    Contains 1 GS domain. 
    Contains 1 protein kinase domain.
     
    SWISS:
    P36894
     
    Gene ID:
    657
     
    Database links:
    Entrez Gene: 657 Human
    Entrez Gene: 12166 Mouse
    Entrez Gene: 81507 Rat
    Omim: 601299 Human
    SwissProt: P36894 Human
    SwissProt: P36895 Mouse
    SwissProt: Q78EA7 Rat
    Unigene: 524477 Human
    Unigene: 237825 Mouse
    Unigene: 88925 Rat
     
     
    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

    Sample: 
    Placenta (Mouse) Lysate at 40 ug
    Primary: Anti-BMPR1A (bs- 1509R) at 1/300 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 60 kD
    Observed band size: 63 kD
    上海雅吉生物科技有限公司
    • 电话:021-3466
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