NCBI Gene Id: 4318
Swissprot Id: P14780
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OAAN00717
Human Intestine
Immunohistochemistry of paraffin-embedded human gastric using MMP9 antibody at dilution of 1:100 (x400 lens).
Mouse Spinal Cord
Western blot analysis of extracts of mouse spinal cord cell lines, using MMP9 antibody.
Multiple Cell Lines
Western blot analysis of extracts of various cell lines, using MMP9 antibody.