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    研选 小鼠肿瘤坏死因子-α酶联免疫试剂盒

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     小鼠肿瘤坏死因子-α酶联免疫试剂盒

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    • 商家诚信度 
    • 入驻年限  3年
    • 北京市通州区马驹桥镇联东U谷西区二号院67号楼
      • 货号:

        bsk00163

      • 样本:

        cell culture supernates, serum, and plasma.

      • 标记物:

      • 适应物种:

        Rat

      • 应用:

        S/P/CC

      • 检测方法:

        ELISA

      • 检测限:

        15 pg/ml

      • 供应商:

        北京博奥森生物技术有限公司

      • 数量:

        100

      • 规格:

        96T

      产品介绍

      中文名称 大鼠肿瘤坏死因子-α酶联免疫试剂盒
      别    名 TNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, Tumour necrosis factor alpha, TNF-α  
      线性范围 31.3 - 2000 pg/ml
      适用样品基质 cell culture supernates, serum, and plasma.
      试剂盒组成 Kit Components 96 wells Quantity/SizeAluminium pouches with a Microwell Plate coated with monoclonal antibody to rat TNF-α (8﹡12) 1 plate Rat TNF-α Standard lyophilized, 2000 pg/ml upon reconstitution 2 vialsConcentrated Biotin-Conjugate anti-rat TNF-α monoclonal antibody 2 vialsStreptavidin-HRP solution 2 vialsStandard /sample Diluent 1 bottleBiotin-Conjugate antibody Diluent 1 bottleStreptavidin-HRP Diluent 1 bottleWash Buffer Concentrate 20x (PBS with 1% Tween-20) 1 bottleSubstrate Solution 1 vialStop Solution 1 vialAdhesive Films 3 piecesProduct data sheet 1 copy
      描述 Sandwich ELISA kit of Quantitative Detection for Rat TNF alp
      保存条件 Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)
      产品介绍 The prototype ligand of theTNFsuperfamily, TNF-α/TNFSF1A, is a pleiotropic cytokine that plays a central role in inflammation and apoptosis.TNF-α is produced by activated macrophages and other cell types including T and B cells, NK cells, LAK cells, astrocytes, endothelial cells, smooth muscle cells and some tumor cells.Rat TNF-α cDNA encodes a 235 amino acid (aa) residue type II membrane protein. The 156 aa residue soluble TNF-α is released from the C-terminus of the membrane-anchored TNF-α by TNF-α-converting enzyme (TACE), a matrix metalloprotease.The membrane-anchored form of TNF-α has been shown to have lytic activity and may also have an important role in intercellular communication. The biologically active TNF-α has been shown to exist as a trimer.TNF-α is reported to promote inflammatory cell infiltration by upregulating leukocyte adhesion molecules on endothelial cells, serve as a chemotactic agent for monocytes, and activate phagocyte killing mechanisms. Deficiencies in either TNF-α or its receptors can increase susceptibility to infection by intracellular pathogens. TNF-α may also play a role in lymphoid tissue development. Knockout mice lack splenic B cell follicles and the ability to form germinal centers. Other potential physiological roles for TNF-α and its receptors include regulating the differentiation of hematopoietic stem and progenitor cells.

      肿瘤坏死因子-α(Tumor Necrosis Factor,简写TNF)是一种能够直接杀伤肿瘤细胞而对正常细胞无明显毒性的细胞因子,是迄今为止所发现的直接杀伤肿瘤作用最强的生物活性因子之一。八十年代在欧美曾展开临床研究,然而由于毒副作用严重而被迫终止。但由于TNF-α明确的抗肿瘤活性,使得学者们不愿轻易放弃。一些临床试验用TNF-α进行隔离肢体或器官灌流,取得了轰动的成果。同时通过对TNF-α的深入研究,研制出一些高效,低毒的TNF-α变构体。因此九十年代末在欧美重新确认了TNF-α抗肿瘤的重要地位。

       
       

      试剂盒优点

      高灵敏度及特异性:可准确识别样本中低含量的目标检测物;

      快速简便操作:无需昂贵设备及相关操作经验;

      稳定性:实验重复性良好,变异系数低;

      种类丰富:提供多种选择性;

      实验数据易于处理分析。



      该产品被文献引用

      Specific References :[IF=4.122] Wang C et al. Chaihulonggumulitang Shows Psycho-cardiology Therapeutic Effects on Acute Myocardial Infarction by Enhancing Bone Marrow Mesenchymal Stem Cells Mobilization. Sci Rep. 2018 Feb 27;8(1):3724.  ELISA ;  Rat. 

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