Deregulation of normal transcription is a feature of all acute leukaemias. In T-cell neoplasms, this is brought about by altered expression of normal transcription factor proteins. This is the result of chromosomal translocations resulting in the promoter and enhancer elements of the T-cell receptor genes TCRA, TCRB, TCRG and TCRD being brought into close proximity with one of these T-cell receptor genes. Know more at: http://www.creative-bioarray.com/TCL1-Breakapart-Probe-FHPC-095-item-4736.htm