简介: 货 号:I-9922 名 称:Ingenol 3-Hexanoate 别 名:Ingenol 3-Hexanoate C A S :83036-61-7 分子量:446.58 分子式:C26H38O6 纯 度:HPLC/TLC:>99% 说 明: 文 献:Ingenol-3-hexanoate was more potent in reactivating latent HIV than other known activators such as SAHA, ingenol 3,20-dibenzoate, TNF-α, PMA and HMBA. Ingenol-3-hexanoate alone was able to reactivate virus transcription in primary HIV-infected latent cells up to 12 fold, and up to 25 fold in combination with SAHA. Pandeló José D., et al. "Reactivation of latent HIV-1 by new semi-synthetic ingenol esters." Virology 462-463: 328-339 (2014).Synthetic ingenol derivatives referred to as ingenol A, B, and C activated the HIV-LTR in reporter cell lines and latent virus in human PBMCs at concentrations as low as 10 nM. They were also able to inhibit the replication of HIV-1 subtype B and C in MT-4 cells and human PBMCs with EC50 values of 0.02 and 0.09 µM respectively. Abreu C.M., et al. "Dual role of novel ingenol derivatives from Euphorbia tirucalli in HIV replication: inhibition of de novo infection and activation of viral LTR." PLoS One 9: e97257 (2014).Highly active antiretroviral therapy (HAART) effectively suppresses HIV viral replication; however, it fails to eradicate latent viral reservoirs. Ingenol-3-hexanoate is a potent activator of latent HIV reservoirs, possibly via protein kinase C[delta]-Nf-[kappa]B signaling. Jiang G., et al. "Reactivation of HIV latency by a newly modified Ingenol derivative via protein kinase Cδ-NF-κB signaling." AIDS 28: 1555-1566 (2014).