Alternative Names LMN; ADLD; LMN2; LMNB; Lamin B1;
Immunogen A synthesized peptide derived from human Lamin B1
Storage Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Purification Affinity-chromatography
Isotype Rabbit IgG
Clonality Monoclonal
Description The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression.
Applications
Reactivity Human,Mouse,Rat
Application WB,IHC,ICC/IF,IP
Recommended dilution WB 1:3000~1:10000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50
All lanes use AB0054 Lamin B1 Antibody at 1:10000 dilution for 1 hour at room temperature.
All lanes use AB0054 Lamin B1 Antibody at 1:20000 dilution for 1 hour at room temperature.
All lanes use AB0054 Lamin B1 Antibody at 1:10000 dilution for 1 hour at room temperature.
Immunohistochemical analysis of paraffin-embedded rat liver, using Lamin B1 Antibody.
Immunofluorescent analysis of HepG2 cells, using Lamin B1 Antibody.
Zinc inhibited LPS-induced inflammatory responses by upregulating A20 expression in microglia BV2 cells. -Journal of Affective Disorders
Euphorbia factor L2 alleviates lipopolysaccharide-induced acute lung injury and inflammation in mice through the suppression of NF-κB activation.-Biochemical Pharmacology
Zinc inhibited LPS-induced inflammatory responses by upregulating A20 expression in microglia BV2 cells.-Journal of Affective Disorders
lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into the nucleus - 2021.9-Cell Death and Differentiation
Overexpression of ARHGAP30 suppresses growth of cervical cancer cells by downregulating ribosome biogenesis-CANCER SCIENCE (CANCER SCI)
Ulmoidol, an unusual nortriterpenoid from Eucommia ulmoides Oliv. Leaves prevents neuroinflammation by targeting the PU.1 transcriptional signaling pathway-Bioorganic Chemistry (BIOORG CHEM)
ILDR1 Promotes Influenza a Virus Replication Through Binding to PLSCR1-Scientific Reports
Ochratoxin A Induces Steatosis via PPARγ-CD36 Axis-Toxins
Inhibiting Importin 4-mediated nuclear import of CEBPD enhances chemosensitivity by repression of PRKDC-driven DNA damage repair in cervical cancer-Oncogene
Euphorbia Factor L2 ameliorates the Progression of K/BxN Serum-Induced Arthritis by Blocking TLR7 Mediated IRAK4/IKKβ/IRF5 and NF-kB Signaling Pathways-Frontiers in Pharmacology (Front Pharmacol)
Sterol sulfate alleviates atherosclerosis via mediating hepatic cholesterol metabolism in ApoE−/− mice-Food & Function (FOOD FUNCT)
Study on the antidepressant effect of panaxynol through the IκB-α/NF-κB signaling pathway to inhibit the excessive activation of BV-2 microglia-Biomedicine & Pharmacotherapy
Salmonella Induces the cGAS-STING-Dependent Type I Interferon Response in Murine Macrophages by Triggering mtDNA Release-mBio