【产品形式】:艾美捷为您提供的100 ug MBD1抗体产品为无色溶液其浓度为0.5 mg/ml溶解于包含有30%甘油, 0.5% BSA, 5 mM EDTA和0.01%硫柳汞的PBS (pH 7.2)缓冲液中.请将该MBD1抗体产品置于-20 °C冷冻保存,建议分装使用以避免反复冻融.
【背景资料】:The MBD family of proteins includes MeCP2, MBD1, MBD2, MBD3 and MBD4. MBD1 (methyl-CpG binding domain protein 1) binds to methylated CpG sites and represses gene transcription. MBD1 is recruited to both methylated and non-methylated CpGs by separate domains: the CXXC domain targets the protein to non-methylated CpGs whereas the MBD domain targets the protein to methylated CpG. MBD1 may also interact with histone methyltransferase SETDB1 to repress transcription.