4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Two alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
Product Information
Product Description:
ABAT( AAH08990, 1 a.a. - 117 a.a.) full-length recombinant protein with GST.
Molecular Weight:
38.87 kDa
Polypeptide Chain:
Human ABAT
Length with Tag:
350 aa with GST tag
Storage Buffer:
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction:
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Quality Control Testing:
12.5% SDS-PAGE Stained with Coomassie Blue
Note:
Best use within one month from the date of receipt of this protein.