Biological descriptionBroad spectrum MMP inhibitor (IC50 values are 6 (MMP1), 7 (MMP2), 1.9 (MMP3), 15 (MMP9), 13 (MMP12), 23 (MMP14), 6 (MMP15), 8 (MMP16) and 17 (MMP20) nM). Pharmacologically active in vivo.
Purity> 98%
Properties
Chemical name(2R)-N4-Hydroxy-N1-[(1S)-2-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide
Molecular Weight388.47
Chemical structure
Molecular formulaC20H28N4O4
CAS Number142880-36-2
PubChem identifier132519
Storage instructionsStore at +4°C.
Solubility overviewSoluble in DMSO to 100 mM
Handling
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 12 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Ma D et al. Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors. Bioorg Med Chem Lett14:47-50 (2004). Read more (PubMed: 14684295) »
Li C et al. Arterial repair after stenting and the effects of GM6001, a matrix metalloproteinase inhibitor. J Am Coll Cardiol39:1852-8 (2002). Read more (PubMed: 12039502) »