Quercetin is a plant-derived flavonoid molecule ubiquitous in nature, displaying potential anti- cancer activity. Quercetin time- and dose-dependently down-regulates the expression of mutant p53 protein at the translational level and arrests cells in the G2-M phase, thereby suppressing cell proliferation (IC50= 7 µg/mL) in human breast cancer cell lines [1]. It also arrests human leukemic T-cells in the late G1 phase [2]. Quercetin inhibits the activity of various enzymes, including tyrosine protein kinase (Trk)[3], Phospholipase A2 [4], cyclooxygenase 2 [5], monoamine-oxidase [6], ornithine decarboxylase [7], 5-lypooxigenase, protein kinase C, and mitochondrial ATPase. Quercetin markedly inhibits PI3K-Akt/PKB pathway in a manner similar to that of the selective PI3K inhibitor LY294002 [8]. Quercetin also acts as a GPR30 (G protein-coupled estrogen receptor) activator [9]. Quercetin has been used as an antioxidant in the treatment of inflammatory diseases and been investigated in several clinical trials.
Chemical Properties
Cas No.: 117-39-5
M. Wt.: 302.24
Formula: C15H10O7
Purity: ≥95% (HPLC)
Synonym: Sophoretin
Chemical Name: 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one