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- 文献和实验
- 技术资料
- 库存:
42
- 供应商:
广州市左克生物
- 规格:
100 μg
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产品简介:
货号:Z04951-100
产品名称:FcRn, His, Cynomolgus/Rhesus macaque
产品规格:100 μg
产品介绍文本:The neonatal Fc receptor (FCRN) is an approximately 45 kDa transmembrane glycoprotein with structural homology to MHC class I proteins. It is widely expressed in endothelial and epithelial cells and plays an important role in IgG homeostasis and antigen presentation by dendritic cells.FCGRT&B2M h...
产品概述HTML:
产品属性HTML:
产品简介HTML:
| Species | Cynomolgus/Rhesus macaque | ||||
| Protein Construction |
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| Purity | > 95% as determined by BisTris PAGE | ||||
| Endotoxin Level | Less than 1EU per μg by the LAL method. | ||||
| Biological Activity | Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch. | ||||
| Expression System | HEK293 | ||||
| Theoretical Molecular Weight | 31.5 kDa (FCGRT) and 11.6 kDa (B2M) | ||||
| Apparent Molecular Weight | Due to glycosylation, the protein migrates to 35-38 kDa (FCGRT) and 13-15 kDa (B2M) based on Bis-Tris PAGE result. | ||||
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). | ||||
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. | ||||
| Storage & Stability | Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles. |
应用指导HTML:
技术背景HTML:
| Target Background | The neonatal Fc receptor (FCRN) is an approximately 45 kDa transmembrane glycoprotein with structural homology to MHC class I proteins. It is widely expressed in endothelial and epithelial cells and plays an important role in IgG homeostasis and antigen presentation by dendritic cells.FCGRT&B2M heterodimer protein (FcRn complex) consist of two subunits: p51, and p14 , and forms an MHC class I-like heterodimer. |
| Synonyms | FcRn alpha chain; FCGRT; FCRN; FCGRT&B2M |
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文献和实验与建议,原MHC的后两个字母HC改为小写,即Mhc(表6-2和6-3)。 表6-2 灵长类动物主要组织相容性复合体的新、旧命名 动 物 种 名 Mhc 名 称 普 通 科 学 新 名 旧 名 Chimpanzee(小黑猩猩) Pan troglodytes Patr ChLA Gorilla(大黑猩猩) Gorilla gorilla Gogo GoLA Orang-utan(猩猩) Pongo pygmaeus Popy OrLA Rhesus macaque(monkey
resource for health care providers. J. Med. Libr. Assoc. 94:343‐348. Rhesus Macaque Genome Sequencing and Analysis Consortium, Gibbs, R.A., Rogers, J., Katze, M.G., Bumgarner, R
Gogo GoLA Orang-utan(猩猩) Pongo pygmaeus Popy OrLA Rhesus macaque(monkey)(猕猴,恒河猴,短尾小猴) Macaca mulanta Mamu RhLA
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