- ￥4329 - 10647
- Biorbyt
- orb1946260
- 英国
- 2026年08月07日
- FC, WB
- Rabbit
- Human, Mouse
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- 文献和实验
- 技术资料
- 抗体名：
Phospho-Chk2 (Thr68) rabbit mAb Antibody 抗体
- 抗体英文名：
Phospho-Chk2 (Thr68) rabbit mAb Antibody
- 浓度：
0.5 mg/mL
- 应用范围：
FC, WB
- 宿主：
Rabbit
- 适应物种：
Human, Mouse
- 保质期：
12 months from date of receipt.
- 抗原来源：
详询
- 目录编号：
orb1946260
- 级别：
科研
- 库存：
99
- 供应商：
Biorbyt
- 标记物：
Unconjugated
- 克隆性：
Monoclonal
- 保存条件：
详询
- 形态：
Liquid
- 亚型：
Rabbit IgG1k
- 免疫原：
详询
- 规格：
20 ul/200 ul
| 规格： | 20 ul | 产品价格： | ￥4329.0 |
|---|---|---|---|
| 规格： | 200 ul | 产品价格： | ￥10647.0 |
描述: Checkpoint kinase 2 (Chk2) plays a major role in the checkpoint response to DNA damage. Chk2 is initially inactive in its monomeric, unphosphorylated form. Phosphorylation at Thr68 induces homodimerization, initiating autophosphorylation within the kinase loop at Ser516 and phorphorylation events within the auto-inhibitory loop at Thr383 and Thr387. After these phosphorylations, active dimers and monomers can then phosphorylate substrates such as Cdc25C and BRCA1. In humans, Chk2 genetic deletion and missense variants have been found to be associated with increased risk of breast and colon cancer. Constitutively phosphorylated Chk2 at Thr68 has been found in many human cancer cell lines, especially ones with mutations in p53.
克隆号: BF34
别名: Serine/threonine-protein kinase Chk2, Cds1 homolog, Hucds2, CHEK2, RAD53
应用稀释比例: 1µg/mL - 0.001µg/mL. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.
免疫原: A synthetic phospho-peptide corresponding to residues surrounding Thr68 of human phospho Chk2
交叉反应: Predicted to work with mouse, rat, and other homologues
防腐剂: 1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% rAlbumin
纯化方法: Protein A+G
研究领域: Cell Biology
UniProt ID: O96017
保存条件: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
备注: For research use only.
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文献和实验Using Phospho‐Motif Antibodies to Determine Kinase Substrates
comprising both the phosphorylated residue and the surrounding residues that determine kinase specificity, with degenerate residues taking up the remaining positions. Currently, several categories of phospho?motif antibody are commercially available
：使用 Anti-phospho-Akt (Ser473) Rabbit mAb 对石蜡包埋的人乳腺癌组织进行免疫组织化学分析。（图 A）使用免疫组化试剂盒M&R HRP/DAB Detection IHC Kit，抗体 1:100 稀释；(图 B) 采用普通免疫组化试剂盒，抗体 1:25 稀释。 图 6 免疫组化实验检测 Erk1/2 表达 注：使用 Anti-Erk1/2 Mouse mAb与p44/42 MAPK （Erk1/2）Rabbit mAb 对正常小鼠心脏组织进行免疫
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