- ￥13338
- Biorbyt
- orb1252734
- 英国
- 2026年07月31日
- FC, IF, IHC, WB
- Mouse
- Human
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- 文献和实验
- 技术资料
- 抗体名：
KRT19 Antibody 抗体
- 抗体英文名：
KRT19 Antibody
- 靶点：
KRT19
- 浓度：
0.2 mg/mL
- 应用范围：
FC, IF, IHC, WB
- 宿主：
Mouse
- 适应物种：
Human
- 保质期：
12 months from date of receipt.
- 抗原来源：
详询
- 目录编号：
orb1252734
- 级别：
科研
- 库存：
99
- 供应商：
Biorbyt
- 标记物：
Unconjugated
- 克隆性：
Monoclonal
- 保存条件：
详询
- 形态：
Liquid
- 亚型：
IgG2a, kappa
- 免疫原：
详询
- 规格：
100 ug
类别: Antibodies
产品子类型: Primary Antibody
描述: KRT19 Antibody
克隆号: A53-B/A2.26
别名: Keratin, type I cytoskeletal 19, Cytokeratin-19, CK-19, Keratin-19, K19, KRT19
应用说明: WB: 1-2 µg/mLFlow Cytometry: 0.5-1 ug/million cellsIF: 1-2 µg/mLIHC (FFPE): 0.5-1 µg/mL for 30 min at RT (1)Prediluted format : incubate for 30 min at RT (2)The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the Cytokeratin 19 antibody to be titered up or down for optimal performance.1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
免疫原: Human breast cancer MCF-7 cells were used as the immunogen for this Cytokeratin 19 antibody.
防腐剂: PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
纯化方法: Protein G affinity chromatography
研究领域: Signal Transduction
UniProt ID: P08727
保存条件: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
备注: For research use only.
产品子类型: Primary Antibody
描述: KRT19 Antibody
克隆号: A53-B/A2.26
别名: Keratin, type I cytoskeletal 19, Cytokeratin-19, CK-19, Keratin-19, K19, KRT19
应用说明: WB: 1-2 µg/mLFlow Cytometry: 0.5-1 ug/million cellsIF: 1-2 µg/mLIHC (FFPE): 0.5-1 µg/mL for 30 min at RT (1)Prediluted format : incubate for 30 min at RT (2)The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the Cytokeratin 19 antibody to be titered up or down for optimal performance.1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
免疫原: Human breast cancer MCF-7 cells were used as the immunogen for this Cytokeratin 19 antibody.
防腐剂: PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
纯化方法: Protein G affinity chromatography
研究领域: Signal Transduction
UniProt ID: P08727
保存条件: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
备注: For research use only.
IHC testing of colon carcinoma stained with Cytokeratin 19 antibody (A53-B/A2.26).
Western blot testing of human samples using of Cytokeratin 19 antibody (A53-B/A2.26).
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显示，CLDN6 可以稳定 YAP1，促进其核转位，从而活化 Hippo 通路。 IP 结果显示 CLDN6 与 YAP1 竞争性结合 TJP2 鉴于 CLDN6 是多次跨膜蛋白，但其不具有（或尚未发现？）配体结合结构域，难以设计小分子药物；而如果使用单抗的话，由于肝细胞癌具有复杂的微环境， T 细胞难以发挥足够的抗体依赖细胞毒性（ADCC）效应杀伤癌细胞。因此，作者设计了靶向 CLDN6 的抗体偶联药物（Antibody-Drug Conjugate, ADC），将细胞毒性药物 DM1 和 CLDN6 抗体
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KRT19 Antibody 抗体，orb1252734，Biorbyt
￥13338
