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- TargetMol
- T6886
- 2026年07月07日
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- 详细信息
- 文献和实验
- 技术资料
- CAS号：
1162656-22-5
- 规格：
1mLx10mM(inDMSO)/1mg/5mg/10mg/25mg/50mg/100mg/200mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥477.0 |
|---|---|---|---|
| 规格： | 1mg | 产品价格： | ￥256.0 |
| 规格： | 5mg | 产品价格： | ￥713.0 |
| 规格： | 10mg | 产品价格： | ￥1192.0 |
| 规格： | 25mg | 产品价格： | ￥2184.0 |
| 规格： | 50mg | 产品价格： | ￥3176.0 |
| 规格： | 100mg | 产品价格： | ￥4680.0 |
| 规格： | 200mg | 产品价格： | ￥6312.0 |
Product Introduction
Bioactivity
| 名称 | MCB-613 |
| 描述 | MCB-613 is an effective steroid receptor coactivator (SRC) stimulator. |
| 细胞实验 | Cells are seeded in 96-well plates and allowed to reach 60% to 70% confluence. After indicated compound treatments, relative numbers of viable cells are measured by MTS assay using the Cell Titer 96 Aqueous One Solution Cell Proliferation Assay.(Only for Reference) |
| 激酶实验 | Luciferase assays: After various compound treatments, cells are lysed in luciferase lysis buffer and assayed for luciferase activity using the ONE-Glo luciferase assay system. All luciferase activities are normalized to protein concentration determined by Bradford assay. |
| 体外活性 | MCB-613 selectively and reversibly binds to the RID of SRC-3, and selectively kills cancer cells including MCF-7 (breast), PC-3 (prostate), H1299 (lung), and HepG2 (liver) cells, without toxicity to mouse primary hepatocytes and mouse embryonic fibroblasts (MEFs). MCB-613 also increases SRCs' interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species (ROS). [1] |
| 体内活性 | In an MCF-7 breast cancer mouse xenograft model, MCB-613 (20 mg/kg, i.p.) significantly and dramatically inhibits the growth of the tumor while causing no obvious animal toxicity and body weight less. [1] |
| 存储条件 | Keep away from moisture,Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : 45.45 mg/mL (149.32 mM), Sonication is recommended. DMSO : 41.67 mg/mL (136.9 mM), Sonication is recommended. 10% DMSO+90% Saline : 4.17 mg/mL (13.7 mM), Solution. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (6.57 mM), Sonication is recommended. |
| 关键字 | Src | MCB-613 | MCB613 | Inhibitor | inhibit |
| 相关产品 | Formamide | Allopurinol | Urea | Kaolin | Aceglutamide | Alginic acid | Metronidazole | Sildenafil citrate | Stavudine | Ethoxyquin | Tamoxifen | Ethyl linoleate |
| 相关库 | Bioactive Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Anti-Pancreatic Cancer Compound Library | Kinase Inhibitor Library | Immunology/Inflammation Compound Library | Membrane Protein-targeted Compound Library | Tyrosine Kinase Inhibitor Library | Ferroptosis Compound Library | Target-Focused Phenotypic Screening Library | Endoplasmic Reticulum Stress Compound Library |
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文献和实验体系，可与质子结合，故其碱性（PKb=8.8）较吡咯(pKb=13.6)强，也比苯胺（pKb=9.3）强，能与强酸作用生成较稳定的盐。但比氨(pKb=4.75)弱，也比脂肪叔胺（三甲胺的pKb=4.22）弱。原因在于吡啶环上未参与共轭体系的这一对未共用电子对处于sp2杂化轨道上，其s成分较sp3杂化轨道多，受原子核束缚强，因而较难与H+结合。 吡啶与水能以任意比例混溶，同时又能溶解大多数极性及非极性有机化合物，它是一个良好的溶剂。吡啶具有高水溶性的原因，除分子极性外，是由于其氮原子上一对未参与环
分子中具有高能键的化合物。在生物体内主要有上式（Ⅰ）和（Ⅱ）两种结构的高能化合物。其作用为贮藏能量（例如 ATP、肌酸磷酸）和作为产生 ATP源的中间代谢产物（例如磷酸烯醇丙酮酸）以及合成反应的中间物质（例如酰基辅酶 A），在蛋白质的结构（ conformation）变化周期的第一阶段上（例如钠钾 ATP酶的羧基磷酸中间体）也具有重要作用。多数高等化合物具有磷酸基，但也有例外。
由不同种元素组成的纯净物叫做化合物。化合物一般有固定的组成。化合物的组成一般可用化学式表示。化合物具有确定的物理性质和化学性质，不同于其组成元素的性质。化合物中的元素不能用简单的机械方法或物理方法分开，而必须用化学方法才能分离。
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