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- 2026年07月07日
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- CAS号：
1170613-55-4
- 规格：
1mg/1mLx10mM(inDMSO)/5mg/10mg/25mg/50mg/100mg
| 规格： | 1mg | 产品价格： | ￥190.0 |
|---|---|---|---|
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥424.0 |
| 规格： | 5mg | 产品价格： | ￥388.0 |
| 规格： | 10mg | 产品价格： | ￥604.0 |
| 规格： | 25mg | 产品价格： | ￥1320.0 |
| 规格： | 50mg | 产品价格： | ￥2056.0 |
| 规格： | 100mg | 产品价格： | ￥2984.0 |
Product Introduction
Bioactivity
| 名称 | A-967079 |
| 描述 | A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively. |
| 动物实验 | Separated by 5 min each, to specific stimulation of the neuronal RF were recorded. Spontaneous and evoked neuronal activity was then measured 5, 15, 25, and 35 min after systemic injection of A-967079 (30 μmol/kg) or vehicle (polyethylene glycol). The intravenous injection of A-967079 or vehicle was completed over a 6-7 min period. The i.v. dose of A-967079 was selected based on extrapolated plasma levels that were effective in behavioral studies . Except for 2 experiments in which two easily distinguished neurons were simultaneously recorded on one electrode, only one neuron was studied per rat. Since only one vehicle was used in these experiments, vehicle data was combined when a clear "no effect' was observed in at least 2-3 animals from a particular subset of groups (OA and sham OA)[1]. |
| 体内活性 | 系统性注射A 967079（30 micromol/kg）降低了无损伤及CFA炎症大鼠在接受同侧后腿有害钳制刺激后的广动态范围（WDR）和伤害特异性（NS）神经元反应。同样，A-967079也减弱了OA及OA-sham大鼠在接受高强度机械刺激（300 g von Frey hair）对膝关节的WDR神经元反应。此外，A-967079还降低了CFA炎症大鼠在低强度机械刺激（10 g von Frey hair）下的WDR神经元反应，但在未受伤大鼠中无明显效果。A-967079注射后CFA炎症大鼠的WDR神经元自发活动也有所减少，但在未受伤、OA及OA-sham动物中未见变化[1]。 |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 125 mg/mL (603.17 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (19.3 mM), Sonication is recommended. |
| 关键字 | TRPVChannel | TRPV Channel | TRPChannel | TRPA1 | TRP Channel | Transient receptor potential channels | Inhibitor | inhibit | A-967079 | A967079 | A 967079 |
| 相关产品 | Camphor | Probenecid | (+)-Camphor | Oleoyl Serotonin | Rosiglitazone | (-)-Menthol | Methyl salicylate | trans-Cinnamaldehyde | Caffeic Acid | Nonivamide | 1,4-Cineole | Pregnenolone |
| 相关库 | Inhibitor Library | Bioactive Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | NO PAINS Compound Library | Ion Channel Targeted Library | Clinical Compound Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Pain-Related Compound Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Drug Library |
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化合物 A 967079【1170613-55-4】
￥190 - 2984
