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- TargetMol
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- CAS号：
153559-49-0
- 规格：
1mLx10mM(inDMSO)/2mg/5mg/10mg/25mg/50mg/100mg/500mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥252.0 |
|---|---|---|---|
| 规格： | 2mg | 产品价格： | ￥119.0 |
| 规格： | 5mg | 产品价格： | ￥170.0 |
| 规格： | 10mg | 产品价格： | ￥228.0 |
| 规格： | 25mg | 产品价格： | ￥342.0 |
| 规格： | 50mg | 产品价格： | ￥471.0 |
| 规格： | 100mg | 产品价格： | ￥698.0 |
| 规格： | 500mg | 产品价格： | ￥1896.0 |
Product Introduction
Bioactivity
| 名称 | Bexarotene |
| 描述 | Bexarotene (LGD1069) is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL). |
| 激酶实验 | Biacore studies: Competition assays are performed on a Biacore S51. A Series S Sensor chip CM5 is derivatized for immobilization of a PentaHis antibody for capture of the His-tagged p53. The level of capture is ~ 200 response units (1 response unit corresponds to 1 pg of protein per mm 2). The concentration of MDM2 protein is kept constant at 300 nM. Test compounds are dissolved in DMSO at 10 mM and further diluted to make a concentration series of inhibitor in each MDM2 test sample. The assays are run at 25 °C in running buffer (10 mM Hepes, 0.15 M NaCl, 2% DMSO). MDM2-p53 binding in the presence of inhibitor is calculated as a percentage of binding in the absence of inhibitor and IC50 is calculated using Microsoft Excel |
| 体外活性 | Bexarotene抑制MMTV-erbB2的小鼠中浸润前乳腺病变,如增生和癌的发展.Bexarotene明显预防动物模型中ER阴性乳腺肿瘤形成,毒性比天然存在的类视色素更低. |
| 体内活性 | Bexarotene抑制CTCL细胞系（MJ,HUT78和11 h）中类视黄醇X受体α和视黄酸受体α蛋白的表达。1 mM和10 mM Bexarotene处理CTCL细胞系（MJ,HUT78和11 h）中96小时,以剂量依赖性方式增加细胞亚G1群和膜联蛋白V结合。Bexarotene处理减少存活的蛋白水平,活化的caspase-3和切割的聚（ADP-核糖）聚合酶,但对所有三种CTCL系中Fas/Fas配体和bcl-2蛋白的表达没有明显影响。Bexarotene在HH和Hut-78细胞中诱导活力丧失和更显著抑制克隆形成增殖,而MJ系表现出抗性。 |
| 存储条件 | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.87 mM), Sonication is recommended. DMSO : 9 mg/mL (25.83 mM), Sonication is recommended. Ethanol : 7 mg/mL (20.09 mM), Heating is recommended. |
| 关键字 | T-cell | selective,?retinoid | RXR | RetinoidReceptor | Retinoid X receptors | Retinoid Receptor | Retinoic acid receptors | RAR/RXR | lymphoma | LGD-1069 | LGD 1069 | Inhibitor | inhibit | cutaneous | Bexarotene | Autophagy | antineoplastic | anti-cancer |
| 相关产品 | Guanidine hydrochloride | Naringin | Enzalutamide | Aceglutamide | Alginic acid | Cysteamine hydrochloride | Hemin | Hydroxychloroquine | Sildenafil citrate | Stavudine | Tamoxifen | Paeonol |
| 相关库 | Bioactive Compound Library | Anti-Cancer Approved Drug Library | Anti-Cancer Active Compound Library | Bioactive Compounds Library Max | EMA Approved Drug Library | Anti-Aging Compound Library | FDA-Approved Drug Library | Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Drug Library | Reprogramming Compound Library |
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贝沙罗汀【153559-49-0】
￥119 - 1896
