- ￥122 - 630
- TargetMol
- T0320
- 2026年07月07日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- CAS号：
64-86-8
- 规格：
1mLx10mM(inDMSO)/1g/50mg/100mg/500mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥156.0 |
|---|---|---|---|
| 规格： | 1g | 产品价格： | ￥630.0 |
| 规格： | 50mg | 产品价格： | ￥122.0 |
| 规格： | 100mg | 产品价格： | ￥159.0 |
| 规格： | 500mg | 产品价格： | ￥432.0 |
Product Introduction
Bioactivity
| 名称 | Colchicine |
| 描述 | Colchicine is an orally active natural alkaloid that acts by inhibiting microtubule polymerization (IC50 = 3 nM) and as a competitive antagonist of the α3 glycine receptor. It possesses broad anti-inflammatory, immunosuppressive, and antifibrotic activities, can inhibit NLRP3 inflammasome activation to prevent NSAID-induced small intestine injury, holds potential for gouty arthritis and rheumatoid arthritis research, and is commonly used to establish Alzheimer’s disease models. |
| 动物实验 | a C57BL/6 background are used. To examine the effects of Colchicine on NSAID-induced small intestinal injury, vehicle or Colchicine (1 or 3 mg/kg) is administered orally 30 min prior to indomethacin administration. Mice received intraperitoneal injections of sterilized phosphate buffered saline or mouse recombinant IL-1β (0.1 μg/kg) 3 h after indomethacin treatment. Vehicle or Colchicine (1 or 3 mg/kg) is also administered to NLRP3?/? mice before indomethacin administration. The lesion index is evaluated 24 h after indomethacin administration and examined mRNA and protein expression of inflammasome components 6 h after indomethacin administration. |
| 体外活性 | 方法：人咽癌细胞 FaDu 和 SNU1041 用 Colchicine (0.0-1 μM) 处理 24-72 h，使用 XTT assay 检测细胞活力。 结果：Colchicine 处理以剂量和时间依赖的方式对 FaDu 和 SNU1041 细胞系都具有细胞毒性作用。[1] 方法：绒毛膜细胞 AFCs 和羊水细胞 CVCs 用 Colchicine (0.15 μg/mL) 处理 3-24 h，使用 Flow Cytometry 检测细胞凋亡情况。 结果：Colchicine 诱导 annexin V 和 PI 双阳性细胞的比例显著增加。[2] |
| 体内活性 | 方法：为研究抗肿瘤活性，将 Colchicine (0.1 mg/kg) 口服给药给携带人咽癌肿瘤 FaDu 的 BALB/c-nu 小鼠，每两天一次，持续十四天。 结果：Colchicine 在下咽癌症模型裸鼠中有效抑制肿瘤生长，而没有严重并发症。[1] 方法：为研究对抗 Fas 抗体诱导的致死性的影响，将 Colchicine (2 mg/kg) 腹腔注射给 C57BL/6 小鼠，24 h 后注射 Jo2 抗体 (10 μg)。 结果：所有用 Colchicine 处理的小鼠都在致命的攻击中存活下来。Colchicine 降低了小鼠对抗 Fas 抗体 Jo2 致死作用的易感性。[3] |
| 存储条件 | Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 257.5 mg/mL (644.65 mM), Sonication is recommended. H2O : 1.33 mg/mL (3.33 mM), Sonication is recommended. |
| 关键字 | MicrotubuleAssociated | Microtubule/Tubulin | Microtubule Associated | microtubule | Inhibitor | inhibit | Colchicine | Autophagy | Apoptosis |
| 相关产品 | Formamide | Urea | Guanidine hydrochloride | Naringin | Aceglutamide | Alginic acid | Metronidazole | Hemin | Hydroxychloroquine | Stavudine | Tamoxifen | Paeonol |
| 相关库 | Inhibitor Library | Alkaloid Natural Product Library | Ancient Chinese Classical Formulas Compound Library | Food as Medicine Compound Library | Anti-Aging Compound Library | Traditional Chinese Medicine Monomer Library | FDA-Approved Drug Library | Natural Product Library | Immunology/Inflammation Compound Library | Microtubule-Targeted Compound Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Drug Library |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验3.73 3.61 3.51 3.44 3.37 3.28 3.18 3.07 2.96 2.85 2.72 12 13 4.96 4.35 4.00 3.77 3.60 3.48 3.39 3.31 3.25 3.15 3.05 2.95 2.84 2.72 2.59 13 14 4.86 4.24 3.89 3.66 3.50 3.38 3.28 3.21 3.15 3.05 2.95 2.84 2.73 2.61 2.49 14 15 4.76 4.15 3.80
78 87 35 20 96 43 84 26 34 91 64 7 84 42 17 53 31 57 24 55 06 88 77 04 74 47 67 21 76 33 50 25 83 92 12 06 76 8 63 01 63 78 59 16 95 55 67 19 98 10 50 71 75 12 86 73 58 07 44 39 52 38 79 9 33 21 12 34 29 78 64 56 07 82 52 42 07 44 38 15 51 00 13 42
5.92 4.75 5.64 6.20 6.62 6.96 7.24 7.47 7.68 7.86 9 3.20 3.95 4.41 4.76 5.02 5.24 5.43 5.59 5.74 4.60 5.43 5.96 6.35 6.66 6.91 7.13 7.33 7.49 10 3.15 3.88 4.33 4.65 4.91 5.12 5.30 5.46 5.60 4.48 5.27 5.77 6.14 6.43 6.67 6.87 7.05 7.21 12 3.08 3.77 4.20
技术资料暂无技术资料 索取技术资料
