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- 2026年07月07日
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- CAS号：
83915-83-7
- 规格：
1mLx10mM(inH2O)/1g/50mg/100mg/500mg
| 规格： | 1mLx10mM(inH2O) | 产品价格： | ￥424.0 |
|---|---|---|---|
| 规格： | 1g | 产品价格： | ￥624.0 |
| 规格： | 50mg | 产品价格： | ￥143.0 |
| 规格： | 100mg | 产品价格： | ￥189.0 |
| 规格： | 500mg | 产品价格： | ￥381.0 |
Product Introduction
Bioactivity
| 名称 | Lisinopril dihydrate |
| 描述 | Lisinopril dihydrate （MK-521) is an orally bioavailable, long-acting angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. |
| 体外活性 | Lisinopril significantly reduces left ventricular (LV) end-diastolic pressure (EDP), pulmonary capillary wedge pressure (PCWP) and end-diastolic stress, addition of atenolol to Lisinopril further reduces EDP and PCWP. [1] Lisinopril is a structural homologue of enalaprilat, differing only in the second amino acid side chain. Lisinopril inhibits Angiotensin-converting enzyme (ACE) in vitro, as well as after parenteral and oral administration to humans; its oral bioavailability is only 25-29%, but it has a longer duration of action than enalapril. [2] |
| 体内活性 | Lisinopril treated SHR rats has significantly raised total cholesterol levels compared to untreated spontaneously hypertensive rats (SHR) rats (+27%), but not compared to lisinopril treated Wistar Kyoto rats (WKY) rats. [3] Lisinopril is a long-acting angiotensin-converting enzyme inhibitor which blocks the renin-angiotensin system (RAS) and reduces systemic blood pressure in rats. Lisinopril reduces the hydroxyproline level and inhibits accumulation of collagens in the pulmonary tissue of the treatment group (paraquat + lisinopril) and per-treatment group (lisinopril + paraquat) in rats. [4] Lisinopril results in preserved ultrafiltration volume (UF), glucose reabsorption (D 1 /D 0 glucose) and peritoneal thickness in rats. [5] Lisinopril (0.2 mg/kg twice a day for 10 days) protects the cell membrane integrity and lessens free radical-induced oxidant stress in guinea pig hearts. [6] |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | H2O : 20 mg/mL (45.3 mM), Sonication is recommended. DMSO : Insoluble |
| 关键字 | MRP1 | MK-521 (dihydrate) | MK-521 | MK521 | MK 521 | ACE |
| 相关产品 | Cholesterol | Sacubitril/Valsartan | Losartan | Captopril | H-ASP-PHE-OH | Clarithromycin | Tranilast | Benzyl benzoate | Ursodeoxycholic acid | Cyclophosphamide | Diisononyl phthalate | Losartan potassium |
| 相关库 | Inhibitor Library | Bioactive Compound Library | Bioactive Compounds Library Max | Failed Clinical Trials Compound Library | Anti-Cardiovascular Disease Compound Library | Anti-COVID-19 Compound Library | FDA-Approved Drug Library | Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Immunology/Inflammation Compound Library | Orally Active Compound Library | Drug Repurposing Compound Library |
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文献和实验橱内操作。 30. 环乙酰亚胺：吸入，摄入，皮肤吸收可造成伤害。戴好手套和护目镜，只在化学通风橱内操作。 31. 磺基蓖麻酸（二水合物）；对黏膜和呼吸系统有极大破坏性。不要吸入粉尘，戴好手套和护目镜，在化学通风橱内操作。 32. 甲氨蝶呤(MTX)：为一种致癌剂和致畸胎剂。吸入，摄入，皮肤吸收可造成伤害。暴露于其中可导致胃肠反应，骨髓抑制，肝或肾损害。戴好手套和护目镜，在化学通风橱内操作。 33. 甲醇：有毒，可致失明。吸入，摄入，皮肤吸收可造成伤害。要有足够的通风以减少挥发
套和护目镜，只在化学通风橱内操作。 （30）环乙酰亚胺：吸入，摄入，皮肤吸收可造成伤害。戴好手套和护目镜，只在化学通风橱内操作。 （31）磺基蓖麻酸（二水合物）；对黏膜和呼吸系统有极大破坏性。不要吸入粉尘，戴好手套和护目镜，在化学通风橱内操作。 （32）甲氨蝶呤（MTX）：为一种致癌剂和致畸胎剂。吸入，摄入，皮肤吸收可造成伤害。暴露于其中可导致胃肠反应，骨髓抑制，肝或肾损害。戴好手套和护目镜，在化学通风橱内操作。 （33）甲醇：有毒，可致失明。吸入，摄入，皮肤
卡托普利 25-100 2-3 依那普利 5-40 2 苯那普利 5-40 1-2 赖诺普利 5-40 1 雷米普利 1.25-20 1 福辛普利 10-40 1 西拉普利 2.5-5 1 培哚普利 4-8 1 喹那普利 10-40 1 群多普利 0.5-4 1 地拉普利 15-60 2 咪哒普利 2.5-10 1 血管紧张素受 体拮抗剂 血钾升高，血管性水 肿
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