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- TargetMol
- T36778
- 2026年07月07日
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- CAS号：
1314118-92-7
- 规格：
25mg/50mg/100mg
| 规格： | 25mg | 产品价格： | ￥8480.0 |
|---|---|---|---|
| 规格： | 50mg | 产品价格： | ￥11040.0 |
| 规格： | 100mg | 产品价格： | ￥14000.0 |
Product Introduction
Bioactivity
| 名称 | MK2-IN-1 |
| 描述 | MK2-IN-1 is a potent and selecitve MAPKAPK2(MK2) inhibitor(IC50=0.11 uM) with a non-ATP competitive binding mode. |
| 体外活性 | MK2-IN-1 was profiled for kinase selectivity by screening against a broad panel of 150 protein kinases at a concentration of 10 μM, and only CK1γ3 was significantly inhibited at greater than 50%. MK2-IN-1 inhibited pro-inflammatory cytokine secretion from the human THP1 acute monocytic leukemia cell line, causing dose-dependent inhibition of LPS-stimulated TNFα and IL6 secretion. MK2-IN-1 also dose dependently inhibited IL1β-stimulated matrixmetalloprotease (MMP)13 secretion from the SW1353 chondrosarcoma cell line and human primary chondrocyte cultures. Of note, given its high degree of selectivity, our data suggest that MK2-IN-1 may be an excellent pharmacologic tool for specifically exploring and validating MK2 biology [3]. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : Soluble |
| 关键字 | MK2-IN-1 | MK-2-IN-1 | MK2IN1 | MK2 Inhibitor | MK2 IN 1 |
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文献和实验近几年来，全国各地的医院、防疫站及血站纷纷购置酶标仪和洗板机来代替人工判读和洗板，减少人为误差和感染途径。本文仅对芬兰雷勃公司的WELLWASH 4MK2洗板机发生的故障及维修方法进行说明，只能是拋砖引玉供各位参考，其它机型可加以参考。由于正负压泵之间有一个压差，使清洗头一直在吸，而电路部分控制一个与内部驱动系统相连的磁力装置引导托盘移动，当移动到位时，打开PINCH阀，让洗液流向清洗头，依次清洗酶标板。故障现象解决方法1、真空低，清洗液的注入量/抽取量不等检查并调整酶标板的位置，调整酶标
the GE InCell 3000 automated imaging platform. The assay utilized a genetically modified HeLa cell line stably expressing mitogen-activated, protein-activating protein kinase-2 fused to enhanced green fluorescent protein (MK2–EGFP) and measured
(Table 1 ). The enzymatic activity of MMP family members is controlled by a group of inhibitor proteins known as the Tissue Inhibitors of Metalloproteinases (TIMPs), which consist of four family members (Table 2 ). Whereas all four TIMPs can inhibit
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