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- TargetMol
- T2705
- 2026年07月07日
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- CAS号：
1421373-62-7
- 规格：
1mLx10mM(inDMSO)/1mg/2mg/5mg/10mg/25mg/50mg/100mg/500mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥698.0 |
|---|---|---|---|
| 规格： | 1mg | 产品价格： | ￥253.0 |
| 规格： | 2mg | 产品价格： | ￥351.0 |
| 规格： | 5mg | 产品价格： | ￥590.0 |
| 规格： | 10mg | 产品价格： | ￥789.0 |
| 规格： | 25mg | 产品价格： | ￥1424.0 |
| 规格： | 50mg | 产品价格： | ￥2216.0 |
| 规格： | 100mg | 产品价格： | ￥3112.0 |
| 规格： | 500mg | 产品价格： | ￥6192.0 |
Product Introduction
Bioactivity
| 名称 | Mutant EGFR inhibitor |
| 描述 | Mutant EGFR inhibitor is a selective and potent Mutated EGFR inhibitor, inhibits L858R activating mutant, the Exonl9 deletion activating mutant and the T790M resistance mutant. |
| 激酶实验 | PLK1 Flash Plate Assay: The human PLK1 enzymatic reaction totaling 30μL contained 50 mM Tris-HCl (pH 8.0), 10 mM MgCl2, 0.02% BSA, 10% glycerol, 1 mM DTT, 100 mM NaCl, 3.3% DMSO, 8 μM ATP, 0.2μCi [γ- 33 P]-ATP, 4 μM peptide substrate (Biotin-AHX-LDETGHLDSSGLQEVHLA-CONH2), and 10 nM recombinant human PLK1[2–369]T210D. The enzymatic reaction mixture, with or without PLK inhibitors, is incubated for 2.5 h at 30℃before termination with 20μL of 150 mM EDTA. Then 25μL of the stopped enzyme reaction mixture is transferred to a 384-well streptavidin coated Image FlashPlate and incubated at room temperature for 3 h. The Image Flash Plate wells are washed three times with 0.02% Tween-20 and then read on the Perkin-Elmer Viewlux. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 22.5 mg/mL (43.27 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (3.85 mM), Sonication is recommended. |
| 关键字 | Mutant EGFR inhibitor | Inhibitor | inhibit | HER1 | ErbB-1 | Epidermal growth factor receptor | EGFR (mutant) | EGFR |
| 相关产品 | Neratinib | Lapatinib | Chalcone | Gefitinib | Erlotinib | Osimertinib | Erlotinib hydrochloride | Afatinib | Lidocaine Hydrochloride hydrate | Genistein | Brigatinib | (S)-Afatinib |
| 相关库 | Inhibitor Library | Anti-Breast Cancer Compound Library | Bioactive Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Hematonosis Compound Library | Membrane Protein-targeted Compound Library | Immunology/Inflammation Compound Library | Tyrosine Kinase Inhibitor Library | Covalent Inhibitor Library | Anti-Prostate Cancer Compound Library | Reprogramming Compound Library |
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文献和实验EGFR and Tumor Suppressor Function in Brain Cancer Development
interventions. Using cutting edge Cre/Lox technologies, we created compound conditional transgenic strains based on a Cre-induced expression of mutant EGFRvIII with the concomitant loss of the Cdkn2a and PTEN tumor suppressor genes. The introduction
antibody and progression in tumor therapy【abstract】EGFR is encoded by the c-erb-B1 proto-oncngene. it is reported that the over-expressed and mutant EGFR have good relationship with tumor.Now it has become a new field in tumor therapy.This text
cancer and other solid tumors: results of a phase I trial.J ClinOncol. 2002 Sep 15;20(18):3815-25. [4] RegalesL, Gong Y, et al, 2009. Dual targeting of EGFR canovercome a majordrug resistance mutation in mousemodels of EGFR mutant lung cancer.J. Clin
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