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- 详细信息
- 文献和实验
- 技术资料
- 亚型:
IgG1
- 形态:
Liquid
- 保存条件:
-20°C
- 克隆性:
单克隆
- 适应物种:
Human immunodeficiency virus 1
- 保质期:
twelve months
- 级别:
一抗
- 供应商:
武汉益普生物科技有限公司
- 宿主:
Human
- 抗体英文名:
InVivoMAb Anti-HIV1 env/Env polyprotein Broadly Neutralizing Antibody (Iv0114)
- 规格:
100μg/1mg
| 规格: | 100μg | 产品价格: | ¥2588.0 |
|---|---|---|---|
| 规格: | 1mg | 产品价格: | ¥9188.0 |
| 产品名 | InVivoMAb Anti-HIV1 env/Env polyprotein Broadly Neutralizing Antibody (Iv0114) |
| 货号 | VK617050 |
| 宿主 | Human |
| 种属反应性 | Human immunodeficiency virus 1 |
| 克隆类型 | Monoclonal |
| 克隆号 | Iv0114 |
| Accession号 | Q03805 |
| 靶标 | Envelope glycoprotein gp160, Env polyprotein, Surface protein gp120, SU, Glycoprotein 120, gp120, Transmembrane protein gp41, TM, Glycoprotein 41, gp41, env, HIV1, HIV-1 |
| 同种型 | IgG1 |
| 应用 | Neutralization |
| 内毒素水平 | Please contact with the lab for this information. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 纯度 | >95% as determined by SDS-PAGE. |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 说明 | For research use only. Not suitable for clinical or therapeutic use. |

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文献和实验HIV envelope glycoprotein (Env) is composed of two non-covalently associated subunits: gp120 and gp41. Panning of phage-displayed antibody libraries against gp140 (covalently linked gp120 and the extracellular portion of gp41) has resulted
Molecular Approaches to AIDS Vaccine Development Using Baculovirus Expression Vectors
) and subsequently to full-blown AIDS, anti-p24 titers are reduced and the viral antigen appears in the circulation of patients. The significance of this reduction in p24 antibody for disease progression is presently not known. High levels of antibodies to env gene
Sci Adv: 最新突破,南开大学邵一鸣教授团队发现两种HIV-1广谱中和抗体
,在 HIV-1 自然感染过程中,部分感染者可产生针对膜蛋白保守区的广谱中和抗体 (broadly neutralizing antibodies, bNAbs)。bNAbs 一般在病毒感染后 2-3 年出现,能以极低浓度中和大部分艾滋病毒株。因此,对 bNAbs 的筛选分离、鉴定及 bNAbs 效应机制的探索是艾滋病疫苗研发的重要路径。 随着高通量中和抗体筛选和单克隆抗体分离技术飞速发展,科学家已从 HIV-1 感染者体内成功分离出上百种 bNAbs。对这些广谱中和抗体的识别表位进行鉴定发现,HIV
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