- ￥598 - 2488
- abinScience
- France
- HB796016
- 2026年04月13日
- ELISA, Bioactivity: FACS, Functional assay, Research in vivo
- Human
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
IgG1-kappa
- 形态：
Liquid
- 保存条件：
-20°C
- 克隆性：
单克隆
- 适应物种：
Human
- 保质期：
12 months
- 级别：
一抗
- 供应商：
武汉研升生物科技有限公司
- 宿主：
Human
- 应用范围：
ELISA, Bioactivity: FACS, Functional assay, Research in vivo
- 抗体英文名：
Research Grade Varlilumab
- 规格：
100μg/1mg
| 规格： | 100μg | 产品价格： | ￥598.0 |
|---|---|---|---|
| 规格： | 1mg | 产品价格： | ￥2488.0 |
| 产品名 | Research Grade Varlilumab |
| 货号 | HB796016 |
| 别名 | 1F5, CDX-1127, 1393344-72-3 |
| 表达系统 | Mammalian Cells |
| 靶标 | CD27L receptor, TNFRSF7, T14, CD27 antigen, Tumor necrosis factor receptor superfamily member 7, CD27, T-cell activation antigen CD27 |
| Accession号 | P26842 |
| 宿主 | Human |
| 种属反应性 | Human |
| 克隆性 | Monoclonal |
| 同种型 | IgG1-kappa |
| 内毒素水平 | Please contact the lab for this information. |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 状态 | Liquid |
| 描述 | Varlilumab is a fully human monoclonal antibody (mAb) that targets CD27, a critical molecule in the activation pathway of lymphocytes. Like CD40, CD27 can be effectively manipulated with activating antibodies to induce potent anti-tumor responses, and may result in less toxicities due to its restricted expression and regulation. Varlilumab is a novel, first-in-class, agonist CD27 antibody that stimulates the CD27 pathway, which results in T-cell activation and anti-tumor activity in tumor models. This first-in-human, dose-escalation and expansion study evaluated the safety, pharmacology, and activity of varlilumab in patients with advanced solid tumors. |
| 背景 | Varlilumab (CDX-1127), a human IgG1κ monoclonal antibody, targets CD27 receptor through reacting with the ligand binding site of CD27. CD27 is a member of the tumor necrosis factor receptor superfamily and expressed on unstimulated T lymphocytes, serving as a potent costimulatory molecule. It has been found that CD27 induces a series of T-cell reactions including T-cell activation, proliferation, survival, and maturation of effector capacity and T-cell memory together with its ligand CD70, which is transiently expressed on antigen-presenting cells. Besides, the interaction of CD27 and CD70 also stimulate B-cell proliferation, generation of plasma cells, production of immunoglobulin and B-cell memory, and induction of the cytolytic activity of natural killer (NK) cells. Moreover, CD27 is considered to function on tumor expansion and activation as it also expressed by regulatory T cells (Tregs), a cell that is associated with the suppression of antitumor immunity. The drug, developed by Celldex Therapeutics, is designed for immunotherapy for patients with solid tumors and hematologic malignancies. Varlilumab is currently conducted with two trails. One is the phase 1B clinical trial for advanced breast or ovarian cancer in combination with ONT-10. Another is the phase 1/2 trial for advanced refractory solid tumors together with anti-PD-1 nivolumab. |
| 保存溶液 | 0.01M PBS, pH 7.4. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 说明 | For research use only. Not suitable for clinical or therapeutic use. |
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