Anti-DNA-PK

Mol Cell：杨薇等揭示 DNA-PK 的激活机制以及自磷酸化对 NHEJ 通路的重要作用​

DNA 双链断裂可由外在因素（电离辐射和活性氧等）或内在因素（DNA 复制错误和 V（D）J 重组等）造成，从而激发 DNA 损伤应答，包括 DNA 修复、细胞周期调控、细胞衰老和细胞凋亡等。 DNA 损伤应答由 PIKK（phosphoinositide-3-kinase-related kinase）家族蛋白激酶催化下游蛋白的磷酸化而启动，包括 DNA-PK（DNA 依赖性蛋白激酶）、ATM（Ataxia Telangiectasia Mutated）和 ATR（ATM-Related

Single-Chain Anti-DNA Fv

(2 ). Natural autoantibodies crossreact with a variety of conserved, and seemingly unrelated, autoantigens. Most of these antibodies are of low affinity, although rare exceptions of high affinity natural anti-DNA antibodies have been reported (3 ). The role

Induction of Anti-Hepatitis B Virus Immune Responses Through DNA Immunization

against HBV structural proteins is not detectable in peripheral blood lymphocytes derived from these individuals. It is known that some chronic HBV-infected individuals spontaneously clear HBV DNA from serum each year, and this phenomenon is often accompanied