- 询价
- Miltenyi Biotec
- 德国
- 130-123-938
- 2025年12月09日
- Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry, Immunocytochemistry
- human cell line
- human, non-human primate
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
HLA-DR, DP, DQ
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
REA332
- 标记物：
FITC
- 适应物种：
human, non-human primate
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry, Immunocytochemistry
- 浓度：
1:50
- 抗体英文名：
HLA-DR, DP, DQ Antibody, anti-human, REAfinity™
- 抗体名：
HLA-DR, DP, DQ Antibody, anti-human, REAfinity™
- 规格：
30 tests in 60 µL
Identification and enumeration of HLA-DR, DP, DQ+ cells by flow cytometryClone REA332 recognizes all major histocompatibility class (MHC) class II HLA-DR, DP, and most DQ antigens. Expressed on the surface of most nucleated cells, MHC class II molecules play an important role in the immune system. They are essential in the defense against infection and are a main consideration in transplantation medicine. In addition to presenting antigenic peptides from predominantly extracellular sources to CD4+ T cells, MHC class II molecules also mediate the thymic selection of T helper cells. MHC class II molecules consist of an α and β chain and are transported to endosomal-lysosomal compartments by the invariant chain. In humans, MHC class II molecules are encoded by three different loci, HLA-DR, -DQ, and -DP, which display 70% similarity to each other. Despite the essential function of MHC class II molecules in immune defense against pathogens, some alleles are frequently linked to immune diseases. | Additional information: Clone REA332 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Denzin, L. et al. (2017) Neutralizing antibody responses to viral infections are linked to the non-classical MHC class II gene H2-Ob. Immunity 47 (2): 310–322. | van Lith, M. et al. (2010) HLA-DP, HLA-DQ, and HLA-DR have different requirements for invariant chain and HLA-DM. J. Biol. Chem. 285 (52): 40800–40808. | Franchini, G. et al. (2018) HIV vaccine candidate activation of hypoxia and the inflammasome in CD14+ monocytes is associated with a decreased risk of SIVmac251 acquisition. Nat Med 24 (6): 847–856. | Jones, E. Y. et al. (2006) MHC class II proteins and disease: a structural perspective. Nat. Rev. Immunol. 6 (4): 271–282. | Nishimura, Y. et al. (1998) Peptide-based molecular analyses of HLA class II-associated susceptibility to autoimmune diseases. Int. Rev. Immunol. 17 (5–6): 229–262. | Hoppstädter, J. et al. (2015) M2 polarization enhances silica nanoparticle uptake by macrophages. Front Pharmacol 6: 55.
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HLA-DR, DP, DQ Antibody, anti-human, FITC, REAfinity™, 30 tests in 60 µL
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