- ￥480 - 1480
- Bioss
- D50826
- 2025年10月17日
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- 详细信息
- 技术资料
- 规格：
2mg/10mg
| 规格： | 2mg | 产品价格： | ￥480.0 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥1480.0 |
| 产品编号 | D50826 |
| 英文名称 | HCI-2509 (SP2509) |
| 中文别名 | Reversible LSD1抑制剂 |
| 性状 | Lyophilized |
| 理论分子量 | 437.9 |
| 保存条件 | Store in dry, dark place for one year. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | HCI-2509 (also named as SP2509 or LSD1-C12) is a highly potent, specific, and reversible Lysine Specific Demethylase-1 (LSD1) inhibitor. It inhibits LSD1 in biochemical assay with an IC50 ~13 nM, and has no activity against monoamine oxidase proteins MAO-A and MAO-B (>300 μM). HCI-2509 is a non-competitive inhibitor to bind LSD1, changes its solution dynamics in a manner distinct from TCP. It has minimal inhibition of CYPs and hERG, shows cellular activity against several cancer cell lines including endometrial, breast, colorectal, pancreatic, and prostate cancer (IC50 ~0.3-2.5 μM). HCI-2509 displayed sing-agent efficacy in multiple xenograft models and had good PK/PD relationship by using tumor histone H3K4 and H3K9 methylation. HCI-2509 serves as a very useful chemical probe to study the target biology of LSD1. |
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HCI-2509 (SP2509)(D50826)-2mg/10mg
￥480 - 1480
