- ￥5800
- Proteintech
- 82202-1-PBS
- 2025年10月09日
- WB, IHC, IF/ICC, FC (Intra), Indirect ELISA
- Rabbit
- human, mouse
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
IgG
- 保存条件：
Store at -80°C.
- 克隆性：
Recombinant
- 标记物：
Unconjugated
- 适应物种：
human, mouse
- 宿主：
Rabbit
- 应用范围：
WB, IHC, IF/ICC, FC (Intra), Indirect ELISA
- 靶点：
Caspase 3/P17/P19
- 抗体英文名：
Caspase 3/P17/P19 Recombinant monoclonal antibody, PBS Only
- 抗体名：
Caspase 3/P17/P19 Recombinant monoclonal antibody, PBS Only
- 规格：
100ug
产品信息
82202-1-PBS targets Caspase 3/P17/P19 in WB, IHC, IF/ICC, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | WB, IHC, IF/ICC, FC (Intra), Indirect ELISA |
| 文献引用应用 | IF |
| 经测试反应性 | human, mouse |
| 文献引用反应性 | mouse |
| 免疫原 |
fusion protein |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | caspase 3, apoptosis-related cysteine peptidase |
| 别名 | CASP3, Caspase3, 5G20, CASP 3, CASP-3 |
| 计算分子量 | 32 kDa |
| 观测分子量 | 32-35 kDa, 17 kDa, 19 kDa |
| GenBank蛋白编号 | NM_004346 |
| 基因名称 | Caspase 3 |
| Gene ID (NCBI) | 836 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P42574 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Caspases, a family of endoproteases, are critical players in cell regulatory networks controlling inflammation and cell death. Initiator caspases (caspase-2, -8, -9, -10, -11, and -12) cleave and activate downstream effector caspases (caspase-3, -6, and -7), which in turn execute apoptosis by cleaving targeted cellular proteins. Caspase 3 (also named CPP32, SCA-1, and Apopain) proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at the beginning of apoptosis. Caspase 3 plays a key role in the activation of sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Caspase 3 can also form heterocomplex with other proteins and performs the molecular mass of 50-70 kDa. This antibody can recognize p17, p19 and p32 of Caspase 3.
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文献和实验| Species | Application | Title |
|---|---|---|
| mouse | IF | mSystems Multi-omics investigation of Porphyromonas gingivalis exacerbating acute kidney injury through the gut-kidney axisAuthors - Ling Dong |
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