- 询价
- 吉满/Genomeditech
- 中国
- GM-87903MAB
- 2026年05月29日
- 小鼠模型评估Treg耗竭对肿瘤生长、免疫检查点疗效、自身免疫炎症或移植耐受的影响。
- 兔
- Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
lgG2a
- 克隆性：
单克隆
- 适应物种：
Mouse
- 库存：
现货
- 供应商：
吉满/Genomeditech
- 宿主：
兔
- 应用范围：
小鼠模型评估Treg耗竭对肿瘤生长、免疫检查点疗效、自身免疫炎症或移植耐受的影响。
- 靶点：
CD25
- 抗体名：
抗小鼠CD25抗体（克隆号：PC-61.5.3）
- 规格：
1 mg
CD25基因编码白细胞表面抗原IL-2受体的α链（IL-2Rα），是T细胞分泌的关键细胞因子IL-2的受体组成部分。IL-2受体在T细胞的增殖和分化中发挥重要作用，而CD25的表达水平则可作为T细胞活化状态的指标。
CD25与调节性T细胞（Tregs）的分化和功能密切相关，因此其抗体可以选择性靶向并清除活化T细胞，尤其是表达CD25的T细胞。
在自身免疫性疾病治疗中，如类风湿性关节炎、系统性红斑狼疮和多发性硬化症，CD25抗体通过减少活化T细胞数量来调节免疫反应，从而缓解症状。
在器官移植中，CD25抗体作为免疫抑制剂，可抑制T细胞活化，降低移植排斥反应，提高移植成功率。
在肿瘤免疫治疗中，CD25抗体通过靶向调节性T细胞，改善肿瘤微环境中的免疫抑制状态，从而恢复抗肿瘤免疫反应。
总体而言，CD25抗体在自身免疫性疾病治疗、器官移植管理及癌症免疫治疗中展现出广泛应用潜力，是调节和优化免疫反应的重要工具。
产品简介
Expression System CHO
Aggregation < 5% as determined by SEC-HPLC
Purity > 95% as determined by SDS-PAGE
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Sterility 0.2 μm Filtered
Target CD25
Clone PC-61.5.3
Alternative Names CD25, Il2r, Ly-43, Il2ra
Source/Isotype Monoclonal mouse lgG2a. Kappa
Application /
Description CD25 antibodies selectively target and deplete activated T cells, particularly those expressing CD25, making them potential therapeutic tools for autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis. They modulate the immune response by reducing the number of activated T cells, thereby alleviating symptoms.In organ transplantation, CD25 antibodies serve as immunosuppressants to prevent the recipient's rejection of the graft, reducing T cell activation and improving transplant success rates. In cancer treatment, CD25 antibodies aim to improve the immune suppression in the tumor microenvironment, restoring anti-tumor immune responses by targeting regulatory T cells. Overall, CD25 antibodies demonstrate broad application potential in the treatment of autoimmune diseases, management of organ transplantation, and cancer immunotherapy, helping to regulate and optimize immune responses.
Formulation phosphate-buffered solution, pH 7.2.
数据展示
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文献和实验secondary antibody review -- data from 99 publications
Signaling 18 IgG Alexa Fluor 488 immunocytochemistry 1:2000 18 IgG Alexa Fluor 568 immunocytochemistry 1:2000 19 donkey IgG HRP western blot 1:3000 detect antibody binding in mouse epithelial cells Amersham Biosciences 19 goat
【翻译】Development trends for monoclonal antibody cancer therapeutics
, first described in 1975 (Ref 6), involved use of mouse-derived hybridomas. However, in humans, murine mAbs were commonly (although not always) ineffective as cancer therapeutics. Studies revealed that murine candidates often had short circulating half-lives
血管里的“斑块清洁工”来了！CD25+调节性T细胞变身CAR-Treg，效果惊人
Journal of Molecular Sciences 23.18 (2022): 10914. [29] Rech, Andrew J., and Robert H. Vonderheide. "Clinical use of anti-CD25 antibody daclizumab to enhance immune responses to tumor antigen vaccination by targeting regulatory T cells." Annals of the New
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