MC38细胞

MC-38/MC-38细胞系/MC-38细胞株/MC-38小鼠结肠癌细胞株

Cell line name MC-38

Synonyms MCA-38; MCA 38; MCA38; MC38; Mouse Colon 38; Murine Carcinoma-38; Colon-38; Colon 38; Colon38; C38

Accession CVCL_B288

Resource Identification Initiative To cite this cell line use: MC-38 (RRID:CVCL_B288)

Comments Doubling time: 24.3 hours (PubMed=16320114).

Omics: Mitochondrial genome sequenced.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Caution: The authors of PubMed=25434994 indicate that they have sequenced the mitochondrial genome of the 'rat' cell line MCA38. Their submitted DNA sequence (KM820832.1) is indeed a rat sequence but is labelled as originating from 'rat isolate 406'.

Derived from site: In situ; Colon; UBERON=UBERON_0001155.

Disease Mouse colon adenocarcinoma (NCIt: C120044)

Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)

Breed/subspecies: C57BL/6.

Hierarchy Children:

CVCL_E1LY (HyCyte MC-38 KO-mCasp8) CVCL_E1LZ (HyCyte MC-38 KO-mCd274) CVCL_D6C1 (HyCyte MC-38 KO-mCxcl9)

CVCL_E1M0 (HyCyte MC-38 KO-mFmr1) CVCL_D6C2 (HyCyte MC-38 KO-mMdm4) CVCL_E1M1 (HyCyte MC-38 KO-mPrmt3)

CVCL_D6C3 (HyCyte MC-38 KO-mStk11) CVCL_D0P4 (MC-38 B2m-KO) CVCL_5I36 (MC-38-CEA-1)

CVCL_5I37 (MC-38-CEA-2) CVCL_5I38 (MC-38-MUC-1) CVCL_XZ58 (MC38 human PDL1)

CVCL_B7NL (MC38-hPD-L1) CVCL_C8VZ (MC38-Luc) CVCL_B7NQ (MC38-Luc-RFP)

CVCL_B7NM (MC38-PD-L1 KO) CVCL_XJ96 (MC38-OVA) CVCL_0A68 (MC38/0)

CVCL_0A67 (MC38Luc1) CVCL_B9CM (MC38Luc4) CVCL_B9CN (MC38Luc8)

CVCL_D7FA (SL4) CVCL_E0XJ (Ubigene MC-38 Alkbh1 KO) CVCL_E0XK (Ubigene MC-38 Arid1a KO)

CVCL_E0XL (Ubigene MC-38 Arid2 KO) CVCL_E0XM (Ubigene MC-38 Atrx KO) CVCL_E0XN (Ubigene MC-38 B2m KO)

CVCL_E0XP (Ubigene MC-38 Cd274 KO) CVCL_E0XQ (Ubigene MC-38 Cd276 KO) CVCL_E0XR (Ubigene MC-38 Cd38 KO)

CVCL_E0XS (Ubigene MC-38 Cd47 KO) CVCL_E0XT (Ubigene MC-38 Epha2 KO) CVCL_E0XU (Ubigene MC-38 Erbb2 KO)

CVCL_E0XW (Ubigene MC-38 Fat1 KO) CVCL_E0XX (Ubigene MC-38 Il1r1 KO) CVCL_E0XY (Ubigene MC-38 Kmt2c KO)

CVCL_E0XZ (Ubigene MC-38 Kmt2d KO) CVCL_E0Y0 (Ubigene MC-38 Lrpprc KO) CVCL_E0Y1 (Ubigene MC-38 Mif KO)

CVCL_E0Y2 (Ubigene MC-38 Rb1 KO) CVCL_E0Y3 (Ubigene MC-38 Siglec15 KO) CVCL_E0Y4 (Ubigene MC-38 Tnfrsf10b KO)

CVCL_E0Y5 (Ubigene MC-38 Tnfrsf14 KO) CVCL_E0Y6 (Ubigene MC-38 Tnfrsf17 KO) CVCL_E0Y7 (Ubigene MC-38 Tnfrsf1b KO)

CVCL_E0Y8 (Ubigene MC-38 Ythdf1 KO)

Sex of cell Female

Category Cancer cell line

STR profile Source(s): Millipore=SCC172; Ubigene=YC-A002

 

Markers:

Mouse STR 1-1 15,16,17

Mouse STR 1-2 18,19,20

Mouse STR 2-1 16

Mouse STR 3-2 14,15

Mouse STR 4-2 20.3

Mouse STR 5-5 16,17 (Ubigene=YC-A002)

17 (Millipore=SCC172)

Mouse STR 6-4 17,18 (Millipore=SCC172)

18 (Ubigene=YC-A002)

Mouse STR 6-7 15,16

Mouse STR 7-1 26.2

Mouse STR 8-1 16

Mouse STR 11-2 16

Mouse STR 12-1 16,17,18 (Millipore=SCC172)

17 (Ubigene=YC-A002)

Mouse STR 13-1 17

Mouse STR 15-3 22.3 (Millipore=SCC172)

22.3,23.3 (Ubigene=YC-A002)

Mouse STR 17-2 15,16

Mouse STR 18-3 15,16

Mouse STR 19-2 13

Mouse STR X-1 27

 

Run an STR similarity search on this cell line

Publications

PubMed=1149045

Corbett T.H., Griswold D.P. Jr., Roberts B.J., Peckham J.C., Schabel F.M. Jr.

Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure.

Cancer Res. 35:2434-2439(1975)

 

PubMed=1255804; DOI=10.1093/jnci/56.4.871

Tan M.H., Holyoke E.D., Goldrosen M.H.

Murine colon adenocarcinomas: methods for selective culture in vitro.

J. Natl. Cancer Inst. 56:871-873(1976)

 

PubMed=16320114; DOI=10.1007/s10585-005-3585-0

Morimoto-Tomita M., Ohashi Y., Matsubara A., Tsuiji M., Irimura T.

Mouse colon carcinoma cells established for high incidence of experimental hepatic metastasis exhibit accelerated and anchorage-independent growth.

Clin. Exp. Metastasis 22:513-521(2005)

 

PubMed=25277546; DOI=10.1186/1471-2164-15-847; PMCID=PMC4198738

Didion J.P., Buus R.J., Naghashfar Z., Threadgill D.W., Morse H.C. 3rd, Pardo-Manuel de Villena F.

SNP array profiling of mouse cell lines identifies their strains of origin and reveals cross-contamination and widespread aneuploidy.

BMC Genomics 15:847.1-847.11(2014)

 

PubMed=25434994; DOI=10.3109/19401736.2014.974176

Zhang C.-F., Yu X.-J., Wang B.-Y., Chen H.-W., Hu C.-E.

Whole mitochondrial genome sequence of a rat colorectal cancer MCA38 cell line.

Mitochondrial DNA A. DNA Mapp. Seq. Anal. 27:2034-2035(2016)