MP46细胞

MP46 /MP46 细胞系/MP46 细胞株/MP46 人眼葡萄膜黑色瘤細胞

Cell line name MP46

Accession CVCL_4D13

Resource Identification Initiative To cite this cell line use: MP46 (RRID:CVCL_4D13)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Characteristics: Established from a patient-derived xenograft.

Doubling time: 110 hours (PubMed=24994677).

Omics: SNP array analysis.

Derived from site: In situ; Eye, uvea; UBERON=UBERON_0001768.

Sequence variations

Mutation; HGNC; 4390; GNAQ; Simple; p.Gln209Leu (c.626A>T); ClinVar=VCV000375955; Zygosity=Unspecified (PubMed=24994677).

Disease Uveal melanoma (NCIt: C7712)

Uveal melanoma (ORDO: Orphanet_39044)

Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell Male

Age at sampling 69Y

Category Cancer cell line

STR profile Source(s): ATCC=CRL-3298; DepMap=ACH-002011; PubMed=24994677

 

Markers:

Amelogenin X

CSF1PO 11

D3S1358 18

D5S818 12

D7S820 11

D8S1179 11,12,15

D13S317 10,12

D16S539 12

D18S51 13

D21S11 30,31

FGA 22,22.2,24

Penta D 9,12

Penta E 12

TH01 9

TPOX 11

vWA 16,17

 

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Publications

PubMed=24994677; DOI=10.1016/j.molonc.2014.06.004; PMCID=PMC5528590

Amirouchene-Angelozzi N., Nemati F., Gentien D., Nicolas A., Dumont A., Carita G., Camonis J., Desjardins L., Cassoux N., Piperno-Neumann S., Mariani P., Sastre-Garau X., Decaudin D., Roman-Roman S.

Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic target.

Mol. Oncol. 8:1508-1520(2014)