MGC-803细胞

Cell line name MGC-803 Synonyms MGC803; MGc80-3 Accession CVCL_5334 Resource Identification Initiative To cite this cell line use: MGC-803 (RRID:CVCL_5334) Comments Problematic cell line: Contaminated. Seems to be an hybrid of HeLa and probably of a gastric cancer cell from an Asian individual. The STR profile is highly similar to that of HeLa yet shows some specific differences that suggest it is an hybrid cell line (PubMed=37543987; PubMed=38079103). Was originally thought to originate from a 53 year old male patient suffering from a poorly differentiated gastric mucinous adenocarcinoma. Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00588. Doubling time: ~25 hours (CelloPub=CLPUB00751); 22.5 hours (PubMed=29683800). Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18). Omics: Secretome proteome analysis by 2D-DE/MS. Omics: SNP array analysis. Omics: Transcriptome analysis by microarray. Omics: Transcriptome analysis by RNAseq. Miscellaneous: Formerly the CCRID database had 2 entries describing this cell line (3111C0001CCC000227, 3131C0001000700084). They were one of the sources for the STR profile of this entry. Misspelling: BGC-803; Note=Occasionally. Misspelling: BGC803; Note=Occasionally. Misspelling: MCG803; GEO=GSM844588. DOI=10.1007/BF02948354 Xiao H., Dong Z.-W., Shou C.-C. Induction of apoptosis in human gastric carcinoma cell line MGC-803 by monoclonal antibody PD4. Chin. J. Cancer Res. 10:169-173(1998) PubMed=24743803 Huang H., Han Y., Wu J., Tian Z.-H., Qu L.-K., Shou C.-C. Establishment of drug resistant cell line of MGC-803 and analysis of differential secretome. Beijing Da Xue Xue Bao Yi Xue Ban 46:183-189(2014) PubMed=28107433; DOI=10.1371/journal.pone.0170384; PMCID=PMC5249119 Huang Y.-Q., Liu Y.-H., Zheng C.-Y., Shen C. Investigation of cross-contamination and misidentification of 278 widely used tumor cell lines. PLoS ONE 12:E0170384-E0170384(2017) PubMed=28851942; DOI=10.1038/s41598-017-09660-w; PMCID=PMC5575032 Bian X.-C., Yang Z.-L., Feng H.-L., Sun H., Liu Y.-Q. A combination of species identification and STR profiling identifies cross-contaminated cells from 482 human tumor cell lines. Sci. Rep. 7:9774-9774(2017) PubMed=29683800; DOI=10.1097/CAD.0000000000000601 Fu L., Yin F., Li X.-R., Han B.-K., Zhang C., Wang J.-W., Wang Y.-Q., Bi Y.-F., Liu H.-M. Generation and characterization of a paclitaxel-resistant human gastric carcinoma cell line. Anticancer Drugs 29:491-502(2018) PubMed=29717028; DOI=10.1042/BSR20180277; PMCID=PMC6050193 Zhang Y.-Q., Yu S.-T., Zhang Z.-Z., Zhao G., Xu J. Long non-coding RNA AK096174 promotes cell proliferation and invasion in gastric cancer by regulating WDR66 expression. Biosci. Rep. 38:BSR20180277.1-BSR20180277.12(2018) PubMed=37543987; DOI=10.1002/ijc.34677 Cao F., Sun H., Yang Z.-L., Bai Y.-H., Hu X., Hou Y.-H., Bian X.-C., Liu Y.-Q. Multiple approaches revealed MGc80-3 as a somatic hybrid with HeLa cells rather than a gastric cancer cell line. Int. J. Cancer 154:155-168(2024) PubMed=38079103; DOI=10.1007/s13577-023-01011-4 Yang M.-M., He J., Xia S.-X., Wang Y.-D., Xiong J., Liao C., Li N., Qu S.-F., Shen C. Investigation of the mixed origins of the MGC-803 cell line reveals that it is a hybrid cell line derived from HeLa. Hum. Cell 37:560-566(2024)