IEC-6细胞

IEC-6/IEC-6细胞系/IEC-6细胞株/IEC-6大鼠小肠隐窝上皮细胞

Cell line name IEC-6

Synonyms IEC 6; IEC6; Intestinal Epithelioid Cell line No. 6

Accession CVCL_0343

Resource Identification Initiative To cite this cell line use: IEC-6 (RRID:CVCL_0343)

Comments Senescence: Capable of at least 10 PDL.

Doubling time: ~20 hours (PubMed=88453); ~50 hours (DSMZ=ACC-111).

Derived from site: In situ; Small intestine; UBERON=UBERON_0002108.

Cell type: Epithelial cell of intestine; CL=CL_0002563.

Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)

Breed/subspecies: Charles River Sprague Dawley (CD(SD)); RS=RS:0000695.

Hierarchy Children:

CVCL_6973 (IEC-CF7) CVCL_A5RH (IEC6-Cdx2L1) CVCL_A5RI (IEC6-Cdx2L2)

CVCL_A5RJ (IEC6-Cdx2MT15)

Sex of cell Male

Age at sampling 18-24D

Category Finite cell line

Publications

PubMed=88453; DOI=10.1083/jcb.80.2.248; PMCID=PMC2110349

Quaroni A., Wands J.R., Trelstad R.L., Isselbacher K.J.

Epithelioid cell cultures from rat small intestine. Characterization by morphologic and immunologic criteria.

J. Cell Biol. 80:248-265(1979)

 

PubMed=7681632; DOI=10.1152/ajplung.1993.264.3.L229

Bijman J., Dalemans W., Kansen M., Keulemans J., Verbeek E., Hoogeveen A.T., De Jonge H., Wilke M., Dreyer D., Lecocq J.-P., Pavirani A., Scholte B.J.

Low-conductance chloride channels in IEC-6 and CF nasal cells expressing CFTR.

Am. J. Physiol. 264:L229-L235(1993)

 

PubMed=8552090; DOI=10.1128/mcb.16.2.619; PMCID=PMC231041

Suh E., Traber P.G.

An intestine-specific homeobox gene regulates proliferation and differentiation.

Mol. Cell. Biol. 16:619-625(1996)

 

PubMed=11925460; DOI=10.1093/jn/132.4.680

Thomas C., Oates P.S.

IEC-6 cells are an appropriate model of intestinal iron absorption in rats.

J. Nutr. 132:680-687(2002)

 

PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040

Gruenert D.C., Willems M., Cassiman J.-J., Frizzell R.A.

Established cell lines used in cystic fibrosis research.

J. Cyst. Fibros. 3:191-196(2004)