SNU-182细胞

SNU-182细胞SNU-182细胞系SNU-182人肝癌细胞

Cell line name SNU-182

Synonyms SNU182; NCI-SNU-182

Accession CVCL_0090

Resource Identification Initiative To cite this cell line use: SNU-182 (RRID:CVCL_0090)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: Liver Cancer Model Repository (LIMORE).

Part of: Seoul National University (SNU) cell line collection.

Population: Korean.

Doubling time: 46 hours (PubMed=7543080); 37.62 hours (PubMed=31378681).

Microsatellite instability: Stable (MSS) (Sanger).

Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).

Omics: Deep exome analysis.

Omics: DNA methylation analysis.

Omics: Genome sequenced.

Omics: miRNA expression profiling.

Omics: Protein expression by reverse-phase protein arrays.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: In situ; Liver; UBERON=UBERON_0002107.

Sequence variations

Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser215Ile (c.644G>T); ClinVar=VCV000376660; Zygosity=Unspecified (PubMed=8824565; PubMed=31378681).

HLA typing Source: PubMed=26589293

Class I

HLA-A A*11:01,30:01

HLA-B B*13:02,55:02

HLA-C C*01:02,06:02

Genome ancestry Source: PubMed=30894373

 

Origin % genome

African 1.29

Native American 0

East Asian, North 65.62

East Asian, South 30.85

South Asian 0

European, North 0

European, South 2.24

Disease Adult hepatocellular carcinoma (NCIt: C7956)

Adult hepatocellular carcinoma (ORDO: Orphanet_210159)

Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell Male

Age at sampling 24Y

Category Cancer cell line

STR profile Source(s): AddexBio=C0015003/4954; ATCC=CRL-2235; Cosmic-CLP=1240216; KCLB=00182; PubMed=25877200; PubMed=31378681

 

Markers:

Amelogenin X,Y

CSF1PO 10,12

D3S1358 16,18 (PubMed=25877200)

17 (KCLB=00182)

D5S818 11,12

D7S820 11

D8S1179 10

D13S317 11,14 (AddexBio=C0015003/4954; ATCC=CRL-2235; Cosmic-CLP=1240216; PubMed=25877200; PubMed=31378681)

14 (KCLB=00182)

D16S539 11,13

D18S51 16

D21S11 29,34.2

FGA 22,24

Penta D 9

Penta E 20

TH01 9

TPOX 8,11

vWA 17 (AddexBio=C0015003/4954; ATCC=CRL-2235; Cosmic-CLP=1240216; PubMed=25877200; PubMed=31378681)

17,18 (KCLB=00182)

 

Run an STR similarity search on this cell linePublications

PubMed=7543080; DOI=10.1002/ijc.2910620308

Park J.-G., Lee J.-H., Kang M.-S., Park K.-J., Jeon Y.-M., Lee H.-J., Kwon H.-S., Park H.-S., Yeo K.-S., Lee K.-U., Kim S.-T., Chung J.-K., Hwang Y.-J., Lee H.-S., Kim C.Y., Lee Y.I., Chen T.-R., Hay R.J., Song S.-Y., Kim W.-H., Ki C.-W., Kim Y.-I.

Characterization of cell lines established from human hepatocellular carcinoma.

Int. J. Cancer 62:276-282(1995)

 

PubMed=8824565; DOI=10.1002/(SICI)1097-0215(19960917)67:6<898::AID-IJC22>3.0.CO;2-X

Kang M.-S., Lee H.-J., Lee J.-H., Ku J.-L., Lee K.P., Kelley M.J., Won Y.-J., Kim S.-T., Park J.-G.

Mutation of p53 gene in hepatocellular carcinoma cell lines with HBX DNA.

Int. J. Cancer 67:898-902(1996)

 

PubMed=19956504; DOI=10.4143/crt.2005.37.1.1; PMCID=PMC2785416

Ku J.-L., Park J.-G.

Biology of SNU cell lines.

Cancer Res. Treat. 37:1-19(2005)

 

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662

Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Cancer Res. 70:2158-2164(2010)

 

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027

Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Nature 483:603-607(2012)

 

PubMed=23505090; DOI=10.1002/hep.26402

Wang K., Lim H.Y., Shi S., Lee J., Deng S.-B., Xie T., Zhu Z., Wang Y.-L., Pocalyko D., Yang W.J., Rejto P.A., Mao M., Park C.-K., Xu J.-C.

Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma.

Hepatology 58:706-717(2013)

 

PubMed=23887712; DOI=10.1038/ncomms3218; PMCID=PMC3731665

Nault J.-C., Mallet M., Pilati C., Calderaro J., Bioulac-Sage P., Laurent C., Laurent A., Cherqui D., Balabaud C., Zucman-Rossi J.

High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.

Nat. Commun. 4:2218.1-2218.7(2013)

 

PubMed=25485619; DOI=10.1038/nbt.3080

Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.

A comprehensive transcriptional portrait of human cancer cell lines.

Nat. Biotechnol. 33:306-312(2015)

 

PubMed=25574106; DOI=10.3748/wjg.v21.i1.311; PMCID=PMC4284350

Cevik D., Yildiz G., Ozturk M.

Common telomerase reverse transcriptase promoter mutations in hepatocellular carcinomas from different geographical locations.

World J. Gastroenterol. 21:311-317(2015)