MOLT4细胞

MOLT-4/MOLT-4细胞系/MOLT-4细胞株/MOLT-4人急性淋巴细胞白血病

Cell line name MOLT-4

Synonyms Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D

Accession CVCL_0013

Resource Identification Initiative To cite this cell line use: MOLT-4 (RRID:CVCL_0013)

Comments Part of: 12th International Histocompatibility Workshop (12IHW) cell line panel.

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: LL-100 blood cancer cell line panel.

Part of: MD Anderson Cell Lines Project.

Part of: NCI Pediatric Preclinical Testing Program (PPTP) cell line panel.

Part of: NCI-60 cancer cell line panel.

Population: Caucasian.

Doubling time: 31.56 +- 1.49 hours (PubMed=24762992); 33 hours (PubMed=17117183); 29 hours (PubMed=20922763); 24-48 hours (CLS=300115); ~40 hours (DSMZ=ACC-362); 27.9 hours (NCI-DTP=MOLT-4).

Microsatellite instability: Instable (MSI-high) (PubMed=10739008; PubMed=11226526; PubMed=31068700; Sanger).

Omics: Array-based CGH.

Omics: CNV analysis.

Omics: Deep antibody staining analysis.

Omics: Deep exome analysis.

Omics: DNA methylation analysis.

Omics: Deep proteome analysis.

Omics: Deep quantitative proteome analysis.

Omics: Fluorescence phenotype profiling.

Omics: lncRNA expression profiling.

Omics: Metabolome analysis.

Omics: Protein expression by reverse-phase protein arrays.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.

Cell type: T-cell; CL=CL_0000084.

PubMed=3335022

Alley M.C., Scudiero D.A., Monks A., Hursey M.L., Czerwinski M.J., Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., Boyd M.R.

Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.

Cancer Res. 48:589-601(1988)

 

PubMed=2140233; DOI=10.1111/j.1440-1827.1990.tb01549.x

Nakano A., Harada T., Morikawa S., Kato Y.

Expression of leukocyte common antigen (CD45) on various human leukemia/lymphoma cell lines.

Acta Pathol. Jpn. 40:107-115(1990)

 

PubMed=2144611; DOI=10.1128/mcb.10.10.5502-5509.1990; PMCID=PMC361264

Cheng J., Haas M.

Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell lines.

Mol. Cell. Biol. 10:5502-5509(1990)

 

PubMed=1765142; DOI=10.1016/0014-5793(91)81402-t

Orita S., Saiga A., Takagi S., Tanaka T., Okumura K., Aono Y., Hinuma Y., Igarashi H.

A novel alternatively spliced viral mRNA transcribed in cells infected with human T cell leukemia virus type 1 is mainly responsible for expressing p21X protein.

FEBS Lett. 295:127-134(1991)

 

PubMed=2041050; DOI=10.1093/jnci/83.11.757

Monks A., Scudiero D.A., Skehan P., Shoemaker R.H., Paull K.D., Vistica D.T., Hose C.D., Langley J., Cronise P., Vaigro-Wolff A., Gray-Goodrich M., Campbell H., Mayo J.G., Boyd M.R.

Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines.

J. Natl. Cancer Inst. 83:757-766(1991)

 

CLPUB00447

Mulivor R.A., Suchy S.F.

1992/1993 catalog of cell lines. NIGMS human genetic mutant cell repository. 16th edition. October 1992.

(In misc. document) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda; USA (1992)

 

PubMed=8316623; DOI=10.2307/3578190

Evans H.H., Ricanati M., Horng M.-F., Jiang Q.-Y., Mencl J., Olive P.L.

DNA double-strand break rejoining deficiency in TK6 and other human B-lymphoblast cell lines.

Radiat. Res. 134:307-315(1993)

 

PubMed=8127147

Heyman M., Grander D., Brondum-Nielsen K., Cederblad B., Liu Y., Xu B., Einhorn S.

Interferon system defects in malignant T-cells.

Leukemia 8:425-434(1994)

 

PubMed=8547074; DOI=10.1111/j.1365-2141.1995.tb05302.x

Siebert R., Willers C.P., Schramm A., Fossa A., Dresen I.M.G., Uppenkamp M.J., Nowrousian M.R., Seeber S., Opalka B.

Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines.

Br. J. Haematol. 91:350-354(1995)

 

DOI=10.11418/jtca1981.15.4_211

Matsuo Y., Okochi A., Ariyasu T., Iimura E., Ohno T.

Identification of cell lines with variable numbers of tandem repeat (VNTR) amplified by polymerase chain reaction.

Tissue Cult. Res. Commun. 15:211-219(1996)