Complete Freund's adjuvant (CF

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Complete Freund's adjuvant (CFA)

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MCE 国际站：Complete Freund's adjuvant (CFA)

产品活性：Complete Freund's adjuvant (CFA) 是因发现者 Jules T. Freund 而获名的、与抗原乳化的免疫佐剂，用于增强动物对抗原 (antigen) 的免疫反应。Complete Freund's adjuvant (CFA) 也是 Th1 型免疫反应的诱导剂和 TLR 配体。Complete Freund's adjuvant (CFA) 包含热杀死的非活性化结核杆菌，并由石蜡油包水乳剂组成。Complete Freund's adjuvant (CFA) 刺激强烈且持久的免疫反应，可用于诱导小鼠的持续性炎症疼痛模型、实验性自身免疫性心肌炎 (EAM) 模型等。Incomplete Freund's adjuvant (IFA) (HY-153808A) 是 Freund's Adjuvant 的另一种类型，刺激的免疫反应较弱。

研究领域：Immunology/Inflammation

作用靶点：Toll-like Receptor (TLR)

In Vitro: Complete Freund's adjuvant (CFA) contains numerous microbial TLR ligands (such as TLRs 2, 4, and 9), is a potent inducer of a Th1-type immune response.

In Vivo: Complete Freund's adjuvant (CFA) can be used in animal modeling to establish a mouse model of persistent inflammatory pain.

Complete Freund's adjuvant (CFA) can elicit a robust antibody response to T-cell-dependent antigens in TLR-deficient mice, which is an T-cell-dependent, antigen-specific antibody response.
Complete Freund's adjuvant (CFA) emulsified with Myosin or Myocarditogenic peptide, then subcutaneously injected (two injections with 7 days apart) into A/J, BALB/c, and IL6KO BALB/c male mice to induce experimental autoimmune myocarditis (EAM) mouse model.
Complete Freund's adjuvant (CFA) widely involves in modeling immunization-induced animal models such as collagen-induced arthritis (CIA), experimental autoimmune encephalomyelitis (EAE), experimental autoimmune thyroiditis (EAT), experimental autoimmune uveitis (EAU), and EAM.
Complete Freund's adjuvant (CFA) plus Thyroglobulin to induce thyroiditis, whereas Incomplete Freund's adjuvant (IFA) (HY-153808A) serves as a sufficient adjuvant for thyroid lesions.
Complete Freund's adjuvant (CFA) is injected into the plantar area of the hind paw of C57BL/6J mice to induce inflammatory pain mouse model.
Complete Freund's adjuvant (CFA) injection on the side contralateral results optogenetic inhibition of ventral pallidum (VP) cholinergic (ChAT) system neurons, and significantly reduces the number of c-Fos-positive neurons in the VP on the photo-inhibited side.

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