KLH conjugated synthetic peptide derived from human Capicua
亚型:
LgG
形态:
液体
应用范围:
说明书
保存条件:
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
浓度:
1mg/ml
规格:
100ul
产品属性:
产品名称
Capicua蛋白抗体
浓度
1mg/ml
型号
EY-01K3865
产品名称:Capicua蛋白抗体 英文名称:Capicua 英文别名:Capicua homolog (Drosophila); Cic; CIC; KIAA0306; Protein capicua homolog; CIC_HUMAN. 交叉反应: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep 标记: Unconjugated 抗体来源: Rabbit 抗体类型: Polyclonal 免疫原: KLH conjugated synthetic peptide derived from human Capicua 蛋白细胞定位: 细胞核 纯化方法: affinity purified by Protein A 亚型: IgG 性状: Liquid 浓度: 1mg/ml 储存液: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件: Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. 背景资料: Capicua is the mammalian ortholog of the drosophilia Cic gene and is part of the HMG-box protein superfamily. Expressed primarily in the fetal brain, Capicua functions as a transciptional repressor and is involved in the development of the nervous system through interaction with the ATXN1 protein. When ATXN1 assembles into stable complexes, it directly binds Capicua, thereby mediating both the activity and expression of Capicua. When Capicua is active, it is able to interact with other developmental proteins to restrict the growth of granule cells and regulate normal neuronal development. Disruptions in the the association of Capicua with proteins such as ATXN1 are thought to cause medulloblastoma, the most common form of perdiatric brain tumor arising from irregular growth of granule cells.