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MMP2 Monoclonal Antibody_货号:E-AB-22242_单克隆抗体
MMP2 Monoclonal Antibody
IHC-p
Mouse
Human;Mouse;Rat
12个月
E-AB-22242
科研级别
999
武汉伊莱瑞特生物科技股份有限公司
Unconjugated
Monoclonal
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
液体
IgG
120μL/60μL/20μL
规格: | 120μL | 产品价格: | ¥2310.0 |
---|---|---|---|
规格: | 60μL | 产品价格: | ¥1420.0 |
规格: | 20μL | 产品价格: | ¥580.0 |
Verified Samples |
Verified Samples in IHC:Human colon carcinoma,Human breast carcinoma
|
Dilution |
IHC 1:100-200
|
Clonality |
Monoclonal
|
Isotype |
IgG
|
Immunogen |
Synthetic Peptide of MMP2
|
Abbre |
MMP2
|
Synonyms |
72 kDa gelatinase;72kD type IV collagenase;CLG 4;CLG 4A;CLG4;CLG4A;Collagenase Type 4 alpha;Collagenase type IV A;Gelatinase A;Gelatinase alpha;Gelatinase neutrophil;Matrix metallopeptidase 2 gelatinase A 72kDa gelatinase 72kDa type IV collagenase;Matrix metalloproteinase 2 (gelatinase A;72kDa gelatinase;72kDa type IV collagenase);Matrix Metalloproteinase 2;Matrix metalloproteinase II;Matrix metalloproteinase-2;MMP 2;MMP II;MMP-2;MMP2;MMP2;MONA;Neutrophil gelatinase;PEX;TBE 1;TBE-1抗体
|
Swissprot |
P08253
|
Cellular Localization |
Secreted>extracellular space>extracellular matrix. Membrane. Nucleus. Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes.
|
Tissue Specificity |
Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate.
|
Concentration |
1 mg/mL
|
Storage |
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
|
Buffer |
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
|
Purification Method |
Protein A purification
|
Research Areas |
Cancer; Cell Biology; Cardiovascular; Metabolism
|
Clone No. |
Clone:1H1
|
Conjugation |
Unconjugated
|
Background |
Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro.PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.
|
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