Y03703 Recombin

产品信息(Information)：

背景介绍(Background)：

The protein is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008]

CD40L acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.

Soluble CD40-ligand (sCD40L) is an 18-kDa functional trimer that is shed from activated T lymphocytes and platelets. It is a soluble form of the cluster of the differentiation 40 ligand (CD40L). CD40 was initially found on antigen-presenting cells (APCs) required for the activation of B-cells during immune responses and is important in T-cell-dependent immunoglobulin class switching. Interactions between CD40 and CD40L regulate cell proliferation, differentiation, apoptosis, and inflammation. Activation of CD40 triggers a wide spectrum of signaling cascades through recruitment of TNFR-associated factors (TRAFs) and stimulating NF-kB signaling. The pathophysiologic function of sCD40L has been investigated mainly in cardiovascular diseases and certain autoimmune disorders. Patients with unstable angina have elevated plasma levels of sCD40L. An increased level of this protein is thus considered a very important factor in the evaluation of cardiovascular disease.

图 CD40/CD40L信号通路

制剂(Formulation)：

Lyophilized from 0.22 μm filtered solution in PBS，5%mannital，0.01% Tween80 pH7.4. 

质量控制(Quality Control)：

Purity: ≥ 95% as determined by reducing SDS-PAGE.    

Endotoxin: ＜ 0.1 EU/ug  as determined by LAL test.

保存(Storage)：

Use a manual defrost freezer and avoid repeated freeze - thaw cycles.
12 months from date of receipt, -20 to -70℃ as supplied.
1 month, 2 to 8℃ under sterile conditions after reconstitution.
6 months, -20 to -70℃ under sterile conditions after reconstitution.    

FOR RESEARCH USE ONLY

参考文献：

[1] Huang J, et al. 2012. Blood. 120(15):3030-8.

[2] Zhang S, et al. 2020. J Clin Med. 9(11):3653.