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MMP-9-IN-4
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Please store the product under the recommended conditions in the Certificate of Analysis.
货期:电询
MedChemExpress LLC
电询
MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 2581824-39-5
MCE 国际站:MMP-9-IN-4
产品活性:MMP-9-IN-4 是一种 MMP-9 抑制剂 (IC50: 7.46 nM),与 MMP-9 形成 H-π 相互作用。MMP-9-IN-4 还抑制 AKT 活性 (IC50: 8.82 nM)。MMP-9-IN-4 具有细胞毒性并诱导细胞凋亡 (apoptosis)。MMP-9-IN-4 可用于癌症研究。
研究领域:Metabolic Enzyme/Protease | PI3K/Akt/mTOR | Apoptosis
作用靶点:MMP | Akt | Apoptosis
In Vitro: MMP-9-IN-4 (compound 11, 0-1 μM approximately, 72 h) shows cytotoxicity to Wi-38, MCF-7, NFS-60, HepG-2 cells.MMP-9-IN-4 (72 h) induces apoptosis in MCF-7, NFS-60 and HepG-2 cells at 3.6 nM, 3.61 nM, 2.2 nM respectively.MMP-9-IN-4 (72 h) induces significant caspase 3/7 activation in MCF-7, NFS-60 and HepG-2 cells at 3.6 nM, 3.61 nM, 2.2 nM respectively .MMP-9-IN-4 (2.2 nM, 24 h) inhibits cell migration in HepG-2 cells.MMP-9-IN-4 has anti-bacterial activity against E.coli with a MIC value of 1.814 μM.
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