Anagliptin阿拉格列汀盐酸盐,1359670-56-

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Anagliptin hydrochloride

CAS No. : 1359670-56-6

MCE 国际站：Anagliptin hydrochloride

产品活性：Anagliptin (SK-0403) hydrochloride 是一种高选择性的、有效的、具有口服活性的二肽酰肽酶 4 (DPP-4) 抑制剂，IC₅₀ 值为 3.8 nM，对 DPP-8 和 DDP-9 的选择性相对较弱，IC₅₀ 值分别为 68 nM 和 60 nM。

研究领域：Metabolic Enzyme/Protease

作用靶点：Dipeptidyl Peptidase

In Vitro: Anagliptin (SK-0403) (0-100 μM; 24 h) attenuates s-DPP-4-induced smooth muscle cells proliferation.
Anagliptin (100 μM; 10 min) reduces TNF-α production in cultured monocytes.
Anagliptin (0.001-10 μM; 24 h) significantly suppresses sterol regulatory element‐binding protein activity in HepG2 cells (21% decrease).

In Vivo: Anagliptin (SK-0403) (0.3%; in diet; 16 weeks) reduces atherosclerotic lesion and does not increase the number of circulating EPCs in apoliporotein E (apoE)-deficient mice.
Anagliptin (0.3%; in diet; 4 weeks) exhibits a lipid‐lowering effect in a hyperlipidemic mice model.

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