疾病模型
[Infectious disease] Ortega-PrietoAM et al. 3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection. Nat Commun. 2018 Feb; 9:pp-pp.
[Diabetes and NASH] Kostrzewski Tet al. Three-dimensional perfused human in vitro model of nonalcoholic fatty liver disease. World J Gastroenterol 2017; 23(2): 204-215
[Oncology] Wheeler SE et al. Spontaneous dormancy of metastatic breast cancer cells in an all-human liver microphysiologic system. Br J Cancer 2014; 111(12): 2342-2350
多器官系统
[2-Organs] Chen WL et al. Integrated Gut/Liver Microphysiological Systems Elucidates Inflammatory Inter- Tissue Crosstalk. Biotechnology and Bioengineering, 2017; 114 (11): 2648-2659
[2-Organs] Dalrymple A et al. The characterization of a human two Organ-on-a-Chip (lung-liver) system which has the potential to measure systemic responses in vitro. Poster presented at Society of Toxicology 57th Annual meeting; 2018 Mar 11-15: San Antonio, Texas.
[4/7/10-Organs] Edington et al. Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies. Sci Rep, 2018. IN PRESS
药物研发
[Drug Safety] Long TJ et al. Modeling Therapeutic Antibody-Small Molecule Drug-Drug Interactions Using a Three-Dimensional Perfusable Human Liver Coculture Platform. Drug Metab Dispos 2016; 44(12): 1940-1948
[Drug Metabolism] Vivares A et al. Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device. Xenobiotica 2015; 45(1): 29-44
[Drug Metabolism] Tsamandouras N et al. Quantitative Assessment of Population Variability in Hepatic
Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System. J Pharmacol Exp Ther 2017; 360(1): 95-105