别 名:ATG13 autophagy related 13 homolog; ATG13_HUMAN; Autophagy related protein 13; Autophagy-related protein 13; FLJ20698; KIAA0652.
货号:YLK-KT0577
分 子 量:57kDa
细胞定位:细胞浆 线粒体
纯化方法:affinity purified by Protein A
储 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
产品介绍:自噬体形成所需的自噬因子。 通过控制 ATG13 和 ULK1 的磷酸化状态以及 ATG13-ULK1-RB1CC1 复合物的调节来调节自噬的 TOR 激酶信号通路的靶标。
Function: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.