别名:MMP-9,92 kDa gelatinase,92 kDa type IV collagenase,Gelatinase B,GELB,CLG4B
序列号:P14780
来源:E.coli
种属:Human
标签:His
序列:539-685aa
预估分子量:16.17 kDa (monomer)
纯度:Greater than 90% by SDS-PAGE
浓度:Reconstitution Dependent
形态:Liquid
应用:ELISA、Western Blot、Antigen Protein
存储缓冲液:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:Store at -20°C. (Avoid repeated freezing and thawing.)
通用注释 亚单元:Exists as monomer or homodimer; disulfide-linked. Exists also as heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1.
功能:May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.
亚细胞位置: Secreted Extracellular space Extracellular matrix
文献
1. Erythropoietin attenuates ischemia–reperfusion induced lung injury by inhibiting tumor necrosis factor-α and matrix metalloproteinase-9 expression
2. Genetic relationship between serum pregnancy-associated plasma protein-A gene polymorphism and ischemic cerebrovascular disease in a Northern Han...
Auth: H Wang, Y Song, C Zhang, et al.
From: 中国神经再生研究 (英文版)
3. Serum Levels of Matrix Metalloproteinases 2 and 9 in Patients with Acute Myocardial Infarction