大家好,我是学儿科临床免疫的,主要方向是儿童原发性免疫缺陷病,在读有关高IgE综合征的文献过程中遇到几个名词百思不得其解,想请教一下大家,
1 Recent studies have demonstrated that hypomorphic mutations in signal transducer and activator of transcription 3 result in the classical multisystem form of HIES, whereas a null mutation in tyrosine kinase 2 causes the autosomal recessive form of HIES that is associated with viral and mycobacterial infections.
就是这个hypomorphic mutations 是什么意思啊?亚等位基因?没有听说过这个名词啊?怎么理解啊?
2 Dominant negative 显负性,这个怎么理解啊?
3 antimorphic mutations ,反效等位基因突变?反效等位基因也没听说过啊?
谢谢大家!我急死啦