新品推荐 | Cytokine-responsive Cell Lines

Inflammatory cytokines, released during infection or disease, recruit and activate immune cells, induce acute-phase proteins, and trigger systemic responses like fever. However, excessive production of these cytokines can cause chronic inflammation, tissue damage, and autoimmune diseases. Understanding their clinical significance has led to targeted therapies that block their activity, offering new treatment options for inflammatory diseases.

Cytokine-responsive Cell Lines: IL-4, IL-6, IL-13, IL-15, IL-23, IL-27

The discovery of new biologics can be greatly facilitated by luciferase reporter cell lines, which respond to cytokine stimulation with increased luciferase activity.

Advantages：

• Sensitive and high signal-to-noise ratio with up to 200-fold induction

• Quantitative: Reliable EC50 and IC50 determination

• Validated, protocols provided for key experiments

   

   

  

 

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